Which bus from Knoxville, TN to St. Louis, MO is the cheapest?

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Compare all timetables for the bus from Knoxville, TN to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to St. Louis, MO from various bus operators like Greyhound US for the next days.

today
$122
tomorrow
$124
Wednesday
$135
Thursday
Friday
Saturday
$121
Sunday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 22h 0m 6:10 PM Knoxville, TN Knoxville Area Transit Bus Stop 3:10 PM St. Louis, MO Gateway Station  Economy $122
Greyhound US 20h 45m 8:00 PM Knoxville, TN Knoxville Area Transit Bus Stop 3:45 PM St. Louis, MO Gateway Station  Economy $138

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 22h 0m 6:10 PM Knoxville, TN Knoxville Area Transit Bus Stop 3:10 PM St. Louis, MO Gateway Station  Economy $124
Greyhound US 21h 5m 7:40 PM Knoxville, TN Knoxville Area Transit Bus Stop 3:45 PM St. Louis, MO Gateway Station  Economy $125
Greyhound US 20h 45m 8:00 PM Knoxville, TN Greyhound Bus Station 3:45 PM St. Louis, MO Gateway Station  Economy $139
  • Did you know that if you travel from Knoxville, TN to St. Louis, MO via Nashville, you can save more than $49? You can find the corresponding connections below.
    • Greyhound US
      16h 10m
      0
      6:10 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $36
      • Waiting Time 7h 30m
    • FlixBus
      5h 55m
      0
      3:25 AM
      Nashville
      5th Ave South Station
      9:20 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $39
    Travel Time is 3h 35m shorter, and you will save $49

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 22h 0m 6:10 PM Knoxville, TN Knoxville Area Transit Bus Stop 3:10 PM St. Louis, MO Gateway Station  Economy $135
Greyhound US 20h 45m 8:00 PM Knoxville, TN Knoxville Area Transit Bus Stop 3:45 PM St. Louis, MO Gateway Station  Economy $159
  • Did you know that if you travel from Knoxville, TN to St. Louis, MO via Nashville, you can save more than $60? You can find the corresponding connections below.
    • Greyhound US
      16h 10m
      0
      6:10 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $36
      • Waiting Time 7h 30m
    • FlixBus
      5h 55m
      0
      3:25 AM
      Nashville
      5th Ave South Station
      9:20 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $39
    Travel Time is 3h 35m shorter, and you will save $60

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 22h 0m 6:10 PM Knoxville, TN Knoxville Area Transit Bus Stop 3:10 PM St. Louis, MO Gateway Station  Economy $121
Greyhound US 20h 45m 8:00 PM Knoxville, TN Knoxville Area Transit Bus Stop 3:45 PM St. Louis, MO Gateway Station  Economy $121
  • Did you know that if you travel from Knoxville, TN to St. Louis, MO via Nashville, you can save more than $46? You can find the corresponding connections below.
    • Greyhound US
      16h 10m
      0
      6:10 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $36
      • Waiting Time 7h 30m
    • FlixBus
      5h 55m
      0
      3:25 AM
      Nashville
      5th Ave South Station
      9:20 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $39
    Travel Time is 3h 35m shorter, and you will save $46

Best Price Offer: The price for the cheapest bus from Knoxville, TN to St. Louis, MO is $100 on 8/14/2026. Flexible travelers save on ticket prices.


Facts about the bus from Knoxville, TN to St. Louis, MO

Compare all providers like Greyhound US that travel 3 times every day by bus from Knoxville, TN to St. Louis, MO in one click! Book your bus ticket from Knoxville, TN to St. Louis, MO starting from $100!

Cheapest Bus $100
Fastest Bus 19h 45m
Earliest Bus 6:10 PM
Latest Bus 8:00 PM
Daily Bus Routes 3 Ø
Distance 391.5 miles
Bus Companies Greyhound US

Cheapest bus connections from Knoxville, TN to St. Louis, MO

Every day, 3 buses from 1 bus companies leave Knoxville, TN for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/27/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 07/26
Monday 07/27
$122
Tuesday 07/28
$124
Wednesday 07/29
$135
Thursday 07/30
Friday 07/31
Saturday 08/01
$121
Sunday 08/02
Monday 08/03
$132
Tuesday 08/04
$169
Wednesday 08/05
$163
Thursday 08/06
Friday 08/07
$108
Saturday 08/08
$115
Sunday 08/09
$119
Monday 08/10
$114
Tuesday 08/11
$112
Wednesday 08/12
Thursday 08/13
Friday 08/14
$100
Saturday 08/15
$100
Sunday 08/16
$106
Monday 08/17
Tuesday 08/18
$111
Wednesday 08/19
$118
Thursday 08/20
$118
Friday 08/21
Saturday 08/22

How to save money travelling from Knoxville, TN to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to St. Louis, MO are also emptier.

All bus stations and stops in Knoxville, TN and St. Louis, MO

In the map below, you can see where to find all bus stations in Knoxville, TN and St. Louis, MO.

Service and Comfort on the bus from Knoxville, TN to St. Louis, MO

Want to know which seat classes are available on the buses from Knoxville, TN to St. Louis, MO? Or which bus companies serve the route Knoxville, TN to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Knoxville, TN to St. Louis, MO bus

How much does a Knoxville, TN St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $100 and takes 21h 0m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $100 and $159. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Knoxville, TN to St. Louis, MO each day?

Every day, the Knoxville, TN to St. Louis, MO bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to St. Louis, MO take?

The fastest bus from Knoxville, TN to St. Louis, MO is offered by Greyhound US and takes 19h 45m. Bus tickets for this connection cost $142. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Knoxville, TN starts at 6:10 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to St. Louis, MO?

The latest bus trip departing from Knoxville, TN for St. Louis, MO starts at 8:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN St. Louis, MO route?

When traveling by bus from Knoxville, TN to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and St. Louis, MO?

You can check all the direct connections between Knoxville, TN and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Knoxville, TN to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Knoxville, TN and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Knoxville, TN to St. Louis, MO?

Prices and availability for 3 trips between Knoxville, TN and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Knoxville, TN to St. Louis, MO

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to St. Louis, MO

Here’s an overview of the most popular bus routes to Knoxville, TN and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to Knoxville, TN and to St. Louis, MO
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