Bus Orlando, FL to Knoxville, TN: Compare prices and save money

Compare all timetables for the bus from Orlando, FL to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Orlando, FL to Knoxville, TN from various bus operators like FlixBus for the next days.

today

$157

tomorrow

$103

Tuesday

Wednesday

$108

Thursday

$100

Friday

$165

Saturday

$114

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	23h 45m	10:55 PM	Orlando, FL	Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$157	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/26/2026 10:55:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/27/2026 10:40:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 23h 45m
FlixBus	30h 10m	3:40 PM	Orlando, FL	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$262	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/26/2026 3:40:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/27/2026 9:50:00 PM. 50 Economy ticket for $262 per person are available. Travel duration is 30h 10m
FlixBus	32h 40m	2:00 PM	Orlando, FL	Florida Mall	10:40 PM	Knoxville, TN	Greyhound Bus Station	Economy	$267	A Bus from FlixBus goes from Florida Mall, Orlando, FL (USA) at 7/26/2026 2:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 7/27/2026 10:40:00 PM. 50 Economy ticket for $267 per person are available. Travel duration is 32h 40m
FlixBus	33h 5m	12:45 PM	Orlando, FL	Florida Mall	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$274	A Bus from FlixBus goes from Florida Mall, Orlando, FL (USA) at 7/26/2026 12:45:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 7/27/2026 9:50:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 33h 5m

Did you know that if you travel from Orlando, FL to Knoxville, TN via Atlanta, GA, you can save more than $62? You can find the corresponding connections below.
- FlixBus
  
  31h 5m
  
  0
  
  2:45 PM
  
  Orlando, FL
  Bus Station
  
  11:25 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $56
  
  A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/27/2026 2:45:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 7/27/2026 11:25:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 8h 40m
- Greyhound US
  
  3h 45m
  
  0
  
  6:05 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:50 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $39
  
  A Bus from Greyhound US goes from Garnett Transit Station, Atlanta, GA (USA) at 7/28/2026 6:05:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 7/28/2026 9:50:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 3h 45m
Travel time is 7h 20m longer, but you will save $62

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	23h 45m	10:55 PM	Orlando, FL	Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$103	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/27/2026 10:55:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/28/2026 10:40:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 23h 45m
FlixBus	15h 50m	6:00 AM	Orlando, FL	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$105	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/27/2026 6:00:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/27/2026 9:50:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 15h 50m
FlixBus	30h 10m	3:40 PM	Orlando, FL	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$130	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/27/2026 3:40:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/28/2026 9:50:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 30h 10m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	23h 45m	10:55 PM	Orlando, FL	Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$108	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/29/2026 10:55:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/30/2026 10:40:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 23h 45m
FlixBus	15h 50m	6:00 AM	Orlando, FL	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$110	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/29/2026 6:00:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/29/2026 9:50:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 15h 50m
FlixBus	30h 10m	3:40 PM	Orlando, FL	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$122	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/29/2026 3:40:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/30/2026 9:50:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 30h 10m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	15h 50m	6:00 AM	Orlando, FL	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$100	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/30/2026 6:00:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/30/2026 9:50:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 15h 50m
FlixBus	23h 45m	10:55 PM	Orlando, FL	Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$108	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/30/2026 10:55:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/31/2026 10:40:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 23h 45m
FlixBus	30h 10m	3:40 PM	Orlando, FL	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$112	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/30/2026 3:40:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/31/2026 9:50:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 30h 10m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	15h 50m	6:00 AM	Orlando, FL	Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$165	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/31/2026 6:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 7/31/2026 9:50:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 15h 50m
FlixBus	23h 45m	10:55 PM	Orlando, FL	Bus Station	10:40 PM	Knoxville, TN	Greyhound Bus Station	Economy	$198	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/31/2026 10:55:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 8/1/2026 10:40:00 PM. 50 Economy ticket for $198 per person are available. Travel duration is 23h 45m
FlixBus	30h 10m	3:40 PM	Orlando, FL	Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$212	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/31/2026 3:40:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 8/1/2026 9:50:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 30h 10m

Did you know that if you travel from Orlando, FL to Knoxville, TN via Atlanta, GA, you can save more than $57? You can find the corresponding connections below.
- FlixBus
  
  22h 55m
  
  0
  
  10:55 PM
  
  Orlando, FL
  Bus Station
  
  7:15 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $69
  
  A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/27/2026 10:55:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 7/28/2026 7:15:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 8h 20m
- Greyhound US
  
  3h 45m
  
  0
  
  6:05 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:50 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $39
  
  A Bus from Greyhound US goes from Garnett Transit Station, Atlanta, GA (USA) at 7/28/2026 6:05:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 7/28/2026 9:50:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 3h 45m
Travel time is 7h 5m longer, but you will save $57

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	23h 45m	10:55 PM	Orlando, FL	Bus Station	10:40 PM	Knoxville, TN	Greyhound Bus Station	Economy	$114	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 8/1/2026 10:55:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 8/2/2026 10:40:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 23h 45m
FlixBus	15h 50m	6:00 AM	Orlando, FL	Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$122	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 8/1/2026 6:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 8/1/2026 9:50:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 15h 50m
FlixBus	30h 10m	3:40 PM	Orlando, FL	Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$143	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 8/1/2026 3:40:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 8/2/2026 9:50:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 30h 10m

Did you know that if you travel from Orlando, FL to Knoxville, TN via Atlanta, GA, you can save more than $14? You can find the corresponding connections below.
- FlixBus
  
  22h 55m
  
  0
  
  10:55 PM
  
  Orlando, FL
  Bus Station
  
  7:15 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $54
  
  A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 8/2/2026 10:55:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 8/3/2026 7:15:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 8h 20m
- Greyhound US
  
  3h 45m
  
  0
  
  6:05 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:50 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $46
  
  A Bus from Greyhound US goes from Garnett Transit Station, Atlanta, GA (USA) at 8/3/2026 6:05:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 8/3/2026 9:50:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 3h 45m
Travel time is 7h 5m longer, but you will save $14

Best Price Offer: The price for the cheapest bus from Orlando, FL to Knoxville, TN is $95 on 8/6/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Orlando, FL and Knoxville, TN

See here how frequent the connections between Orlando, FL and Knoxville, TN are, during different times and days of the week.

Sunday is the busiest day, with more than 6 daily buses from Orlando, FL to Knoxville, TN. Saturday has instead the fewest connections, with only 3 daily coaches between Orlando, FL and Knoxville, TN.

The busiest time of the day is the Afternoon, with 13 buses from Orlando, FL to Knoxville, TN, while Morning sees the fewest connections between Orlando, FL and Knoxville, TN, with 9 offers.

Facts about the bus from Orlando, FL to Knoxville, TN

Compare all providers like FlixBus that travel 5 times every day by bus from Orlando, FL to Knoxville, TN in one click! Book your bus ticket from Orlando, FL to Knoxville, TN starting from $95!

Cheapest Bus	$95
Fastest Bus	15h 50m
Earliest Bus	12:45 PM
Latest Bus	10:55 PM
Daily Bus Routes	5 Ø
Distance	534.0 miles
Bus Companies	FlixBus

Cheapest bus connections from Orlando, FL to Knoxville, TN

Every day, 5 buses from 1 bus companies leave Orlando, FL for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

$157

Monday 07/27

$103

Tuesday 07/28

Wednesday 07/29

$110

Thursday 07/30

$102

Friday 07/31

$165

Saturday 08/01

$114

Sunday 08/02

$110

Monday 08/03

$104

Tuesday 08/04

$103

Wednesday 08/05

Thursday 08/06

$95

Friday 08/07

$102

Saturday 08/08

Sunday 08/09

Monday 08/10

$101

Tuesday 08/11

$105

Wednesday 08/12

$98

Thursday 08/13

$97

Friday 08/14

Saturday 08/15

$102

Sunday 08/16

Monday 08/17

Tuesday 08/18

$113

Wednesday 08/19

Thursday 08/20

$96

Friday 08/21

$101

Saturday 08/22

The cheapest time to travel from Orlando, FL to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Orlando, FL to Knoxville, TN, for the next 30 days.

With a price starting from $95, Thursday is the cheapest day for a bus from Orlando, FL to Knoxville, TN. Sunday instead is the most expensive day with prices starting from $110.

Morning is the cheapest day time for bus tickets from Orlando, FL to Knoxville, TN, with $100. Afternoon is the most expensive time of the day with prices starting from $112.

How to save money travelling from Orlando, FL to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Orlando, FL to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Orlando, FL to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Orlando, FL to Knoxville, TN are also emptier.

All bus stations and stops in Orlando, FL and Knoxville, TN

In the map below, you can see where to find all bus stations in Orlando, FL and Knoxville, TN.

Bus Station

N John Young Pkwy 555

Florida Mall

Florida Mall Avenue 1602

RedCoach Station

Belle Isle

Universal Studio Orlando Resort

Universal Blvd 5800

Seaworld Hotels

International Dr 10100

Kingston Pike

Kingston Pike 6927

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

Service and Comfort on the bus from Orlando, FL to Knoxville, TN

Want to know which seat classes are available on the buses from Orlando, FL to Knoxville, TN? Or which bus companies serve the route Orlando, FL to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Orlando, FL to Knoxville, TN bus

How much does a Orlando, FL Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $95 and takes 15h 50m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Orlando, FL to Knoxville, TN?

This route is offered by 1 companies with a range of ticket prices between $95 and $274. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Orlando, FL to Knoxville, TN each day?

Every day, the Orlando, FL to Knoxville, TN bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Orlando, FL to Knoxville, TN take?

The fastest bus from Orlando, FL to Knoxville, TN is offered by FlixBus and takes 15h 50m. Bus tickets for this connection cost $112. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Orlando, FL to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Orlando, FL starts at 12:45 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Orlando, FL to Knoxville, TN?

The latest bus trip departing from Orlando, FL for Knoxville, TN starts at 10:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Orlando, FL Knoxville, TN route?

When traveling by bus from Orlando, FL to Knoxville, TN, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Orlando, FL and Knoxville, TN?

You can check all the direct connections between Orlando, FL and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Orlando, FL to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Orlando, FL Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Orlando, FL Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Orlando, FL to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Orlando, FL to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Orlando, FL and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Orlando, FL to Knoxville, TN?

Prices and availability for 5 trips between Orlando, FL and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Orlando, FL to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Orlando, FL and to Knoxville, TN

Here’s an overview of the most popular bus routes to Orlando, FL and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!