Bus San Antonio, TX to Knoxville, TN: Compare prices and save money

Compare all timetables for the bus from San Antonio, TX to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to Knoxville, TN from various bus operators like FlixBus, Greyhound US or Valley Transit for the next days.

today

$125

tomorrow

Monday

Tuesday

$127

Wednesday

Thursday

$129

Friday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	37h 5m	7:45 AM	San Antonio, TX	Pearl District	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$125	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 10/24/2026 7:45:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/25/2026 9:50:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 37h 5m
Greyhound US	31h 20m	1:30 PM	San Antonio, TX	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$125	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/24/2026 1:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/25/2026 9:50:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 31h 20m
FlixBus	23h 35m	9:55 PM	San Antonio, TX	Bus Station	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$140	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 10/24/2026 9:55:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/25/2026 10:30:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 23h 35m

Cheapest bus trips Tuesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	31h 20m	1:30 PM	San Antonio, TX	Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station		Economy	$127	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/27/2026 1:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 10/28/2026 9:50:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 31h 20m
	FlixBus	23h 35m	9:55 PM	San Antonio, TX	Bus Station	10:30 PM	Knoxville, TN	Greyhound Bus Station		Economy	$132	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 10/27/2026 9:55:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 10/28/2026 10:30:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 23h 35m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Valley Transit	24h 30m	9:00 PM	San Antonio, TX	Bus Station	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$129	A Bus from Valley Transit goes from Bus Station, San Antonio, TX (USA) at 10/29/2026 9:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/30/2026 10:30:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 24h 30m
FlixBus	37h 5m	7:45 AM	San Antonio, TX	Pearl District	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$130	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 10/29/2026 7:45:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/30/2026 9:50:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 37h 5m
Greyhound US	31h 20m	1:30 PM	San Antonio, TX	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$138	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/29/2026 1:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/30/2026 9:50:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 31h 20m

Best Price Offer: The price for the cheapest bus from San Antonio, TX to Knoxville, TN is $110 on 11/12/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Antonio, TX and Knoxville, TN

See here how frequent the connections between San Antonio, TX and Knoxville, TN are, during different times and days of the week.

Thursday is the busiest day, with more than 6 daily buses from San Antonio, TX to Knoxville, TN. Tuesday has instead the fewest connections, with only 2 daily coaches between San Antonio, TX and Knoxville, TN.

The busiest time of the day is the Afternoon, with 4 buses from San Antonio, TX to Knoxville, TN, while Morning sees the fewest connections between San Antonio, TX and Knoxville, TN, with 3 offers.

Facts about the bus from San Antonio, TX to Knoxville, TN

Compare all providers like FlixBus, Greyhound US and Valley Transit that travel 3 times every day by bus from San Antonio, TX to Knoxville, TN in one click! Book your bus ticket from San Antonio, TX to Knoxville, TN starting from $110!

Cheapest Bus	$110
Fastest Bus	24h 35m
Earliest Bus	7:45 AM
Latest Bus	9:00 PM
Daily Bus Routes	3 Ø
Distance	958.9 miles
Bus Companies	FlixBus, Greyhound US and Valley Transit

Cheapest bus connections from San Antonio, TX to Knoxville, TN

Every day, 3 buses from 3 bus companies leave San Antonio, TX for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/24/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/18

Monday 10/19

Tuesday 10/20

Wednesday 10/21

Thursday 10/22

Friday 10/23

Saturday 10/24

$125

Sunday 10/25

Monday 10/26

Tuesday 10/27

$127

Wednesday 10/28

Thursday 10/29

$133

Friday 10/30

Saturday 10/31

$141

Sunday 11/01

Monday 11/02

$122

Tuesday 11/03

$120

Wednesday 11/04

Thursday 11/05

$118

Friday 11/06

Saturday 11/07

Sunday 11/08

$114

Monday 11/09

$118

Tuesday 11/10

Wednesday 11/11

Thursday 11/12

$110

Friday 11/13

Saturday 11/14

The cheapest time to travel from San Antonio, TX to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to Knoxville, TN, for the next 30 days.

With a price starting from $110, Thursday is the cheapest day for a bus from San Antonio, TX to Knoxville, TN. Saturday instead is the most expensive day with prices starting from $125.

Morning is the cheapest day time for bus tickets from San Antonio, TX to Knoxville, TN, with $125. Evening is the most expensive time of the day with prices starting from $129.

How to save money travelling from San Antonio, TX to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to Knoxville, TN are also emptier.

Beloved bus companies from San Antonio, TX to Knoxville, TN

These are the most booked bus companies between San Antonio, TX to Knoxville, TN from our users.

Valley Transit from San Antonio, TX to Knoxville, TN

Here you will find the key facts about the Valley Transit bus route San Antonio, TX to Knoxville, TN:

Cheapest Price	$129
Fastest Bus	25h 30m
Earliest Bus	9:00 PM
Last Bus	9:00 PM
Daily Connections	1 Ø
Found on	9/29/2026

All bus stations and stops in San Antonio, TX and Knoxville, TN

In the map below, you can see where to find all bus stations in San Antonio, TX and Knoxville, TN.

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

Service and Comfort on the bus from San Antonio, TX to Knoxville, TN

Want to know which seat classes are available on the buses from San Antonio, TX to Knoxville, TN? Or which bus companies serve the route San Antonio, TX to Knoxville, TN? Below you will find answers to your questions.

FAQs about the San Antonio, TX to Knoxville, TN bus

How much does a San Antonio, TX Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $110 and takes 38h 5m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to Knoxville, TN?

This route is offered by 3 companies with a range of ticket prices between $110 and $142. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from San Antonio, TX to Knoxville, TN each day?

Every day, the San Antonio, TX to Knoxville, TN bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to Knoxville, TN take?

The fastest bus from San Antonio, TX to Knoxville, TN is offered by FlixBus and takes 24h 35m. Bus tickets for this connection cost $140. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from San Antonio, TX starts at 7:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to Knoxville, TN?

The latest bus trip departing from San Antonio, TX for Knoxville, TN starts at 9:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX Knoxville, TN route?

When traveling by bus from San Antonio, TX to Knoxville, TN, passengers can travel with FlixBus, Greyhound US and Valley Transit. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and Knoxville, TN?

You can check all the direct connections between San Antonio, TX and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound US and Valley Transit.

What can I take with me on the San Antonio, TX to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from San Antonio, TX to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between San Antonio, TX and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Antonio, TX to Knoxville, TN?

Prices and availability for 3 trips between San Antonio, TX and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Antonio, TX to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to Knoxville, TN

Here’s an overview of the most popular bus routes to San Antonio, TX and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!