Bus Greenville, SC to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Greenville, SC to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to St. Louis, MO from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

Wednesday

Thursday

$92

Friday

Saturday

Sunday

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	14h 0m	8:20 PM	Greenville, SC	Woodruff Rd	9:20 AM	St. Louis, MO	Gateway Station		Economy	$92	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/30/2026 8:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/31/2026 9:20:00 AM. 50 Economy ticket for $92 per person are available. Travel duration is 14h 0m
	FlixBus	24h 45m	9:35 PM	Greenville, SC	Woodruff Rd	9:20 PM	St. Louis, MO	Gateway Station		Economy	$93	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 7/30/2026 9:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/31/2026 9:20:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 24h 45m

Did you know that if you travel from Greenville, SC to St. Louis, MO via Atlanta, GA, you can save more than $10? You can find the corresponding connections below.
- Greyhound US
  
  14h 0m
  
  0
  
  8:20 PM
  
  Greenville, SC
  Woodruff Rd
  
  11:30 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $24
  
  A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/30/2026 8:20:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 7/30/2026 11:30:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 3h 10m
- FlixBus
  
  10h 21m
  
  0
  
  11:59 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:20 AM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $58
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 7/30/2026 11:59:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/31/2026 9:20:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 10h 21m
Travel time is 1h 0m longer, but you will save $10

Best Price Offer: The price for the cheapest bus from Greenville, SC to St. Louis, MO is $74 on 8/10/2026. Flexible travelers save on ticket prices.

Facts about the bus from Greenville, SC to St. Louis, MO

Compare all providers like Greyhound US and FlixBus that travel 2 times every day by bus from Greenville, SC to St. Louis, MO in one click! Book your bus ticket from Greenville, SC to St. Louis, MO starting from $74!

Cheapest Bus	$74
Fastest Bus	13h 0m
Earliest Bus	8:20 PM
Latest Bus	9:35 PM
Daily Bus Routes	2 Ø
Distance	504.7 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Greenville, SC to St. Louis, MO

Every day, 2 buses from 2 bus companies leave Greenville, SC for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/27/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

Monday 07/27

Tuesday 07/28

Wednesday 07/29

Thursday 07/30

$92

Friday 07/31

Saturday 08/01

Sunday 08/02

Monday 08/03

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

$81

Friday 08/07

Saturday 08/08

Sunday 08/09

Monday 08/10

$74

Tuesday 08/11

$92

Wednesday 08/12

$99

Thursday 08/13

$85

Friday 08/14

$84

Saturday 08/15

$85

Sunday 08/16

Monday 08/17

Tuesday 08/18

$93

Wednesday 08/19

Thursday 08/20

$86

Friday 08/21

$84

Saturday 08/22

How to save money travelling from Greenville, SC to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to St. Louis, MO are also emptier.

All bus stations and stops in Greenville, SC and St. Louis, MO

In the map below, you can see where to find all bus stations in Greenville, SC and St. Louis, MO.

McDonald's

Woodruff Rd 1111

N Church St

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

Woodruff Rd

Woodruff Rd 1116

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Greenville, SC to St. Louis, MO

Want to know which seat classes are available on the buses from Greenville, SC to St. Louis, MO? Or which bus companies serve the route Greenville, SC to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Greenville, SC to St. Louis, MO bus

How much does a Greenville, SC St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $74 and takes 13h 0m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to St. Louis, MO?

This route is offered by 2 companies with a range of ticket prices between $74 and $93. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Greenville, SC to St. Louis, MO each day?

Every day, the Greenville, SC to St. Louis, MO bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to St. Louis, MO take?

The fastest bus from Greenville, SC to St. Louis, MO is offered by Greyhound US and takes 13h 0m. Bus tickets for this connection cost $92. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Greenville, SC starts at 8:20 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to St. Louis, MO?

The latest bus trip departing from Greenville, SC for St. Louis, MO starts at 9:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC St. Louis, MO route?

When traveling by bus from Greenville, SC to St. Louis, MO, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and St. Louis, MO?

You can check all the direct connections between Greenville, SC and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Greenville, SC to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Greenville, SC and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to St. Louis, MO?

Prices and availability for 2 trips between Greenville, SC and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to St. Louis, MO

Here’s an overview of the most popular bus routes to Greenville, SC and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!