Bus Florence, SC to Greenville, SC - Compare all Companies

Compare all timetables for the bus from Florence, SC to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Greenville, SC from various bus operators like FlixBus for the next days.

today

tomorrow

$90

Friday

$92

Saturday

Sunday

$108

Monday

$99

Tuesday

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	14h 25m	5:45 AM	Florence, SC	TA Travel Center	8:10 PM	Greenville, SC	Woodruff Rd		Economy	$90	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/10/2026 5:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 9/10/2026 8:10:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 14h 25m
	FlixBus	10h 45m	12:05 AM	Florence, SC	TA Travel Center	10:50 AM	Greenville, SC	Woodruff Rd		Economy	$107	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/10/2026 12:05:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 9/10/2026 10:50:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 10h 45m

Did you know that if you travel from Florence, SC to Greenville, SC via Charlotte, you can save more than $9? You can find the corresponding connections below.
- FlixBus
  
  10h 45m
  
  0
  
  12:05 AM
  
  Florence, SC
  TA Travel Center
  
  8:20 AM
  
  Charlotte
  W Trade St
  
  0
  
  Economy
  
  $59
  
  A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/12/2026 12:05:00 AM to W Trade St, Charlotte (USA) arriving at 9/12/2026 8:20:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 8h 15m
- Greyhound US
  
  1h 55m
  
  0
  
  8:55 AM
  
  Charlotte
  W Trade St
  
  10:50 AM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $22
  
  A Bus from Greyhound US goes from W Trade St, Charlotte (USA) at 9/12/2026 8:55:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 9/12/2026 10:50:00 AM. 50 Economy ticket for $22 per person are available. Travel duration is 1h 55m
Travel time is the same as the direct connection, but you will save $9

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	13h 50m	5:45 AM	Florence, SC	TA Travel Center	7:35 PM	Greenville, SC	Woodruff Rd		Economy	$92	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/11/2026 5:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 9/11/2026 7:35:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 13h 50m
	FlixBus	10h 45m	12:05 AM	Florence, SC	TA Travel Center	10:50 AM	Greenville, SC	Woodruff Rd		Economy	$102	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/11/2026 12:05:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 9/11/2026 10:50:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 10h 45m

Did you know that if you travel from Florence, SC to Greenville, SC via Charlotte, you can save more than $13? You can find the corresponding connections below.
- Greyhound US
  
  14h 40m
  
  0
  
  3:20 PM
  
  Florence, SC
  Bus Station
  
  9:00 PM
  
  Charlotte
  W Trade St
  
  0
  
  Economy
  
  $29
  
  A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/12/2026 3:20:00 PM to W Trade St, Charlotte (USA) arriving at 9/12/2026 9:00:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 5h 40m
- Wanda Coach
  
  1h 15m
  
  0
  
  4:45 AM
  
  Charlotte
  Pilot Travel Center gas station
  
  6:00 AM
  
  Greenville, SC
  McDonald's
  
  0
  
  Economy
  
  $50
  
  A Bus from Wanda Coach goes from Pilot Travel Center gas station, Charlotte (USA) at 9/13/2026 4:45:00 AM to McDonald's, Greenville, SC (USA) arriving at 9/13/2026 6:00:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 1h 15m
Travel time is 3h 55m longer, but you will save $13

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	13h 50m	5:45 AM	Florence, SC	TA Travel Center	7:35 PM	Greenville, SC	Woodruff Rd		Economy	$108	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/13/2026 5:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 9/13/2026 7:35:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 13h 50m
	FlixBus	10h 45m	12:05 AM	Florence, SC	TA Travel Center	10:50 AM	Greenville, SC	Woodruff Rd		Economy	$120	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/13/2026 12:05:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 9/13/2026 10:50:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 10h 45m

Did you know that if you travel from Florence, SC to Greenville, SC via Charlotte, you can save more than $30? You can find the corresponding connections below.
- FlixBus
  
  10h 45m
  
  0
  
  12:05 AM
  
  Florence, SC
  TA Travel Center
  
  8:20 AM
  
  Charlotte
  W Trade St
  
  0
  
  Economy
  
  $63
  
  A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/15/2026 12:05:00 AM to W Trade St, Charlotte (USA) arriving at 9/15/2026 8:20:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 8h 15m
- Greyhound US
  
  1h 55m
  
  0
  
  8:55 AM
  
  Charlotte
  W Trade St
  
  10:50 AM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $15
  
  A Bus from Greyhound US goes from W Trade St, Charlotte (USA) at 9/15/2026 8:55:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 9/15/2026 10:50:00 AM. 50 Economy ticket for $15 per person are available. Travel duration is 1h 55m
Travel time is the same as the direct connection, but you will save $30

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	13h 50m	5:45 AM	Florence, SC	TA Travel Center	7:35 PM	Greenville, SC	Woodruff Rd		Economy	$99	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/14/2026 5:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 9/14/2026 7:35:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 13h 50m
	FlixBus	10h 45m	12:05 AM	Florence, SC	TA Travel Center	10:50 AM	Greenville, SC	Woodruff Rd		Economy	$116	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/14/2026 12:05:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 9/14/2026 10:50:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 10h 45m

Did you know that if you travel from Florence, SC to Greenville, SC via Charlotte, you can save more than $21? You can find the corresponding connections below.
- FlixBus
  
  10h 45m
  
  0
  
  12:05 AM
  
  Florence, SC
  TA Travel Center
  
  8:20 AM
  
  Charlotte
  W Trade St
  
  0
  
  Economy
  
  $63
  
  A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/15/2026 12:05:00 AM to W Trade St, Charlotte (USA) arriving at 9/15/2026 8:20:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 8h 15m
- Greyhound US
  
  1h 55m
  
  0
  
  8:55 AM
  
  Charlotte
  W Trade St
  
  10:50 AM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $15
  
  A Bus from Greyhound US goes from W Trade St, Charlotte (USA) at 9/15/2026 8:55:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 9/15/2026 10:50:00 AM. 50 Economy ticket for $15 per person are available. Travel duration is 1h 55m
Travel time is the same as the direct connection, but you will save $21

Best Price Offer: The price for the cheapest bus from Florence, SC to Greenville, SC is $76 on 9/25/2026. Flexible travelers save on ticket prices.

Facts about the bus from Florence, SC to Greenville, SC

Compare all providers like FlixBus that travel 2 times every day by bus from Florence, SC to Greenville, SC in one click! Book your bus ticket from Florence, SC to Greenville, SC starting from $76!

Cheapest Bus	$76
Fastest Bus	10h 45m
Earliest Bus	12:05 AM
Latest Bus	5:45 AM
Daily Bus Routes	2 Ø
Distance	156.6 miles
Bus Companies	FlixBus

Cheapest bus connections from Florence, SC to Greenville, SC

Every day, 2 buses from 1 bus companies leave Florence, SC for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/09/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/06

Monday 09/07

Tuesday 09/08

Wednesday 09/09

Thursday 09/10

$90

Friday 09/11

$92

Saturday 09/12

$88

Sunday 09/13

$108

Monday 09/14

$99

Tuesday 09/15

$119

Wednesday 09/16

Thursday 09/17

$80

Friday 09/18

Saturday 09/19

$95

Sunday 09/20

Monday 09/21

$101

Tuesday 09/22

$110

Wednesday 09/23

Thursday 09/24

Friday 09/25

$76

Saturday 09/26

Sunday 09/27

Monday 09/28

$84

Tuesday 09/29

$127

Wednesday 09/30

Thursday 10/01

Friday 10/02

Saturday 10/03

How to save money travelling from Florence, SC to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Greenville, SC are also emptier.

All bus stations and stops in Florence, SC and Greenville, SC

In the map below, you can see where to find all bus stations in Florence, SC and Greenville, SC.

Bus Station

S Irby St 611

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

South Carolina Federal Gas Station

N Church St

Woodruff Rd

Woodruff Rd 1116

McDonald's

Woodruff Rd 1111

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

Service and Comfort on the bus from Florence, SC to Greenville, SC

Want to know which seat classes are available on the buses from Florence, SC to Greenville, SC? Or which bus companies serve the route Florence, SC to Greenville, SC? Below you will find answers to your questions.

FAQs about the Florence, SC to Greenville, SC bus

How much does a Florence, SC Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $76 and takes 14h 25m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Greenville, SC?

This route is offered by 1 companies with a range of ticket prices between $76 and $120. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Florence, SC to Greenville, SC each day?

Every day, the Florence, SC to Greenville, SC bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Greenville, SC take?

The fastest bus from Florence, SC to Greenville, SC is offered by FlixBus and takes 10h 45m. Bus tickets for this connection cost $107. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Greenville, SC?

The earliest bus arriving in Greenville, SC from Florence, SC starts at 12:05 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Greenville, SC?

The latest bus trip departing from Florence, SC for Greenville, SC starts at 5:45 AM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Greenville, SC route?

When traveling by bus from Florence, SC to Greenville, SC, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Greenville, SC?

You can check all the direct connections between Florence, SC and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Florence, SC to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Florence, SC to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Florence, SC and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Florence, SC to Greenville, SC?

Prices and availability for 2 trips between Florence, SC and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Florence, SC to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Greenville, SC

Here’s an overview of the most popular bus routes to Florence, SC and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!