Bus from Prague to Brussels from $59

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Prague to Brussels

Here is a selection of the cheapest bus trips from the schedule from Prague to Brussels from various bus operators like FlixBus, European Sleeper or BlaBlaCar Bus for the next days.

today
$85
tomorrow
$95
Saturday
$79
Sunday
$75
Monday
$72
Tuesday
$65
Wednesday
$62

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 19h 0m 5:45 PM Prague Na Knížecí Station 12:45 PM Brussels Midi Bus Station  Economy $85
FlixBus 18h 5m 11:50 PM Prague Wilsonova Bus Station 5:55 PM Brussels North Station  Economy $86
BlaBlaCar Bus 19h 45m 7:00 PM Prague ÚAN Florenc 2:45 PM Brussels Midi Bus Station  Economy $106
European Sleeper 16h 30m 6:00 PM Prague Wilsonova Bus Station 10:30 AM Brussels Midi Bus Station  Economy $251
  • Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than $13? You can find the corresponding connections below.
    • RegioJet
      20h 25m
      0
      11:00 PM
      Prague
      ÚAN Florenc
      8:05 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      RegioJet
      Economy
      $46
      • Waiting Time 7h 30m
    • BlaBlaCar Bus
      3h 50m
      0
      3:35 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      7:25 PM
      Brussels
      Midi Bus Station
      0
      BlaBlaCar Bus
      Economy
      $26
    Travel time is 3h 55m longer, but you will save $13

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 30m 3:25 AM Prague Wilsonova Bus Station 5:55 PM Brussels North Station  Economy $95
FlixBus 14h 15m 3:40 AM Prague Na Knížecí Station 5:55 PM Brussels North Station  Economy $95
FlixBus 13h 20m 10:35 AM Prague ÚAN Florenc 11:55 PM Brussels North Station  Economy $99
FlixBus 15h 5m 4:15 PM Prague ÚAN Florenc 7:20 AM Brussels Midi Bus Station  Economy $99
FlixBus 14h 50m 11:05 PM Prague ÚAN Florenc 1:55 PM Brussels Midi Bus Station  Economy $102
  • Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than $21? You can find the corresponding connections below.
    • FlixBus
      17h 15m
      0
      8:40 PM
      Prague
      Na Knížecí Station
      6:20 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      FlixBus
      Economy
      $56
      • Waiting Time 2h 55m
    • FlixBus
      4h 40m
      0
      9:15 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      1:55 PM
      Brussels
      Midi Bus Station
      0
      FlixBus
      Economy
      $18
    Travel time is 3h 55m longer, but you will save $21

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 30m 3:25 AM Prague Wilsonova Bus Station 5:55 PM Brussels North Station  Economy $79
FlixBus 14h 15m 3:40 AM Prague Na Knížecí Station 5:55 PM Brussels North Station  Economy $79
FlixBus 15h 5m 4:15 PM Prague ÚAN Florenc 7:20 AM Brussels Midi Bus Station  Economy $79
FlixBus 13h 20m 10:35 AM Prague ÚAN Florenc 11:55 PM Brussels North Station  Economy $83
FlixBus 14h 50m 11:05 PM Prague ÚAN Florenc 1:55 PM Brussels Midi Bus Station  Economy $83
  • Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than $13? You can find the corresponding connections below.
    • RegioJet
      15h 40m
      0
      11:00 PM
      Prague
      ÚAN Florenc
      8:05 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      RegioJet
      Economy
      $46
      • Waiting Time 2h 5m
    • FlixBus
      4h 30m
      0
      10:10 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      2:40 PM
      Brussels
      North Station
      0
      FlixBus
      Economy
      $21
    Travel time is 2h 20m longer, but you will save $13

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 50m 11:05 PM Prague ÚAN Florenc 1:55 PM Brussels Midi Bus Station  Economy $75
FlixBus 13h 20m 11:05 AM Prague ÚAN Florenc 12:25 AM Brussels North Station  Economy $83
FlixBus 14h 30m 3:25 AM Prague Wilsonova Bus Station 5:55 PM Brussels North Station  Economy $90
European Sleeper 15h 27m 6:00 PM Prague Wilsonova Bus Station 9:27 AM Brussels Midi Bus Station  Economy $359
  • Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than $10? You can find the corresponding connections below.
    • RegioJet
      15h 40m
      0
      11:00 PM
      Prague
      ÚAN Florenc
      8:05 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      RegioJet
      Economy
      $46
      • Waiting Time 2h 5m
    • FlixBus
      4h 30m
      0
      10:10 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      2:40 PM
      Brussels
      North Station
      0
      FlixBus
      Economy
      $19
    Travel time is 2h 20m longer, but you will save $10

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 50m 11:05 PM Prague ÚAN Florenc 1:55 PM Brussels Midi Bus Station  Economy $72
FlixBus 14h 30m 3:25 AM Prague Wilsonova Bus Station 5:55 PM Brussels North Station  Economy $75
FlixBus 14h 15m 3:40 AM Prague Na Knížecí Station 5:55 PM Brussels North Station  Economy $75
FlixBus 13h 20m 11:05 AM Prague ÚAN Florenc 12:25 AM Brussels North Station  Economy $77
FlixBus 16h 50m 8:40 PM Prague Na Knížecí Station 1:30 PM Brussels North Station  Economy $79
  • Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than $8? You can find the corresponding connections below.
    • FlixBus
      15h 45m
      0
      3:40 AM
      Prague
      Na Knížecí Station
      3:05 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      FlixBus
      Economy
      $49
      • Waiting Time 0h 30m
    • BlaBlaCar Bus
      3h 50m
      0
      3:35 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      7:25 PM
      Brussels
      Midi Bus Station
      0
      BlaBlaCar Bus
      Economy
      $16
    Travel time is 2h 25m longer, but you will save $8

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 50m 11:05 PM Prague ÚAN Florenc 1:55 PM Brussels Midi Bus Station  Economy $65
FlixBus 15h 5m 4:15 PM Prague ÚAN Florenc 7:20 AM Brussels Midi Bus Station  Economy $67
FlixBus 17h 0m 1:45 AM Prague Wilsonova Bus Station 6:45 PM Brussels North Station  Economy $70
European Sleeper 17h 0m 6:00 PM Prague Wilsonova Bus Station 11:00 AM Brussels Midi Bus Station  Economy $350

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 15h 5m 4:15 PM Prague ÚAN Florenc 7:20 AM Brussels Midi Bus Station  Economy $62
FlixBus 14h 50m 11:05 PM Prague ÚAN Florenc 1:55 PM Brussels Midi Bus Station  Economy $62
FlixBus 14h 30m 3:25 AM Prague Wilsonova Bus Station 5:55 PM Brussels North Station  Economy $69
FlixBus 14h 15m 3:40 AM Prague Na Knížecí Station 5:55 PM Brussels North Station  Economy $69
FlixBus 13h 20m 11:05 AM Prague ÚAN Florenc 12:25 AM Brussels North Station  Economy $69

Best Price Offer: The price for the cheapest bus from Prague to Brussels is $59 on 8/3/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Prague and Brussels

See here how frequent the connections between Prague and Brussels are, during different times and days of the week.
Monday is the busiest day, with more than 38 daily buses from Prague to Brussels. Friday has instead the fewest connections, with only 34 daily coaches between Prague and Brussels.
The busiest time of the day is the Evening, with 103 buses from Prague to Brussels, while Night sees the fewest connections between Prague and Brussels, with 28 offers.

Facts about the bus from Prague to Brussels

Compare all providers like FlixBus, European Sleeper and BlaBlaCar Bus that travel 37 times every day by bus from Prague to Brussels in one click! Book your bus ticket from Prague to Brussels starting from $59!

Cheapest Bus $59
Fastest Bus 13h 20m
Earliest Bus 1:45 AM
Latest Bus 11:50 PM
Daily Bus Routes 37 Ø
Distance 446.6 miles
Bus Companies FlixBus, European Sleeper and BlaBlaCar Bus

Cheapest bus connections from Prague to Brussels

Every day, 37 buses from 3 bus companies leave Prague for Brussels: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/23/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 07/19
Monday 07/20
Tuesday 07/21
Wednesday 07/22
Thursday 07/23
$106
Friday 07/24
$95
Saturday 07/25
$79
Sunday 07/26
$75
Monday 07/27
$72
Tuesday 07/28
$65
Wednesday 07/29
$62
Thursday 07/30
$67
Friday 07/31
$77
Saturday 08/01
$71
Sunday 08/02
$69
Monday 08/03
$59
Tuesday 08/04
$62
Wednesday 08/05
$62
Thursday 08/06
$64
Friday 08/07
$71
Saturday 08/08
$67
Sunday 08/09
$75
Monday 08/10
$65
Tuesday 08/11
$62
Wednesday 08/12
$59
Thursday 08/13
$97
Friday 08/14
$67
Saturday 08/15

The cheapest time to travel from Prague to Brussels

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Brussels, for the next 30 days.
With a price starting from $55, Tuesday is the cheapest day for a bus from Prague to Brussels. Sunday instead is the most expensive day with prices starting from $67.
Night is the cheapest day time for bus tickets from Prague to Brussels, with $55. Morning is the most expensive time of the day with prices starting from $69.

How to save money travelling from Prague to Brussels

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Brussels in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Brussels, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Prague to Brussels are also emptier.

All bus stations and stops in Prague and Brussels

In the map below, you can see where to find all bus stations in Prague and Brussels.

Service and Comfort on the bus from Prague to Brussels

Want to know which seat classes are available on the buses from Prague to Brussels? Or which bus companies serve the route Prague to Brussels? Below you will find answers to your questions.

FAQs about the Prague to Brussels bus

How much does a Prague Brussels bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $59 and takes 15h 5m to reach Brussels. Compare offers to save money!

How much could I save by comparing buses from Prague to Brussels?

This route is offered by 3 companies with a range of ticket prices between $59 and $359. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Brussels.

On average, how many connections are available from Prague to Brussels each day?

Every day, the Prague to Brussels bus route is served by approximately 37 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Prague to Brussels take?

The fastest bus from Prague to Brussels is offered by FlixBus and takes 13h 20m. Bus tickets for this connection cost $115. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Prague to Brussels?

The earliest bus arriving in Brussels from Prague starts at 1:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Prague to Brussels?

The latest bus trip departing from Prague for Brussels starts at 11:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Prague Brussels route?

When traveling by bus from Prague to Brussels, passengers can travel with FlixBus, European Sleeper and BlaBlaCar Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Prague and Brussels?

You can check all the direct connections between Prague and Brussels by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, European Sleeper and BlaBlaCar Bus.

What can I take with me on the Prague to Brussels bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Prague Brussels bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Brussels bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Brussels on your planned travel date.

How does CheckMyBus find the best bus deals from Prague to Brussels?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 37 daily trips between Prague and Brussels. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Prague to Brussels?

Prices and availability for 37 trips between Prague and Brussels change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Prague to Brussels

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Brussels

Here’s an overview of the most popular bus routes to Prague and to Brussels. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses to Prague from Banska Bystrica Buses to Prague from Banska Bystrica
Bus to Prague from Olomouc Bus to Prague from Olomouc
Bus to Prague from Klagenfurt Bus to Prague from Klagenfurt
Rome to Prague bus Rome to Prague bus
Buses from Freiburg to Brussels Buses from Freiburg to Brussels
Buses Granada - Brussels Buses Granada - Brussels
Bus to Brussels from Ivano-Frankivsk Bus to Brussels from Ivano-Frankivsk
Bus Salzburg - Brussels Bus Salzburg - Brussels
Popular Airport Shuttles to Prague and to Brussels
CheckMyBus › Buses in Czech Republic › Bus to Prague › Bus to Brussels

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.