Bus Florence, SC to Jacksonville, FL

Compare all timetables for the bus from Florence, SC to Jacksonville, FL

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Jacksonville, FL from various bus operators like Greyhound US or FlixBus for the next days.

today

$51

tomorrow

$51

Friday

$83

Saturday

$52

Sunday

$82

Monday

$44

Tuesday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 45m	5:45 AM	Florence, SC	TA Travel Center	11:30 AM	Jacksonville, FL	Amtrak Train Station	Economy	$51	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/9/2026 5:45:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 9/9/2026 11:30:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 5h 45m
Greyhound US	14h 50m	4:10 PM	Florence, SC	Bus Station	7:00 AM	Jacksonville, FL	Downtown Bus Stop	Economy	$81	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/9/2026 4:10:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/10/2026 7:00:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 14h 50m
Greyhound US	18h 50m	12:10 PM	Florence, SC	Bus Station	7:00 AM	Jacksonville, FL	Downtown Bus Stop	Economy	$89	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/9/2026 12:10:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/10/2026 7:00:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 18h 50m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 45m	5:45 AM	Florence, SC	TA Travel Center	11:30 AM	Jacksonville, FL	Amtrak Train Station	Economy	$51	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/10/2026 5:45:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 9/10/2026 11:30:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 5h 45m
Greyhound US	16h 5m	2:55 PM	Florence, SC	Bus Station	7:00 AM	Jacksonville, FL	Downtown Bus Stop	Economy	$82	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/10/2026 2:55:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/11/2026 7:00:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 16h 5m
Greyhound US	18h 50m	12:10 PM	Florence, SC	Bus Station	7:00 AM	Jacksonville, FL	Downtown Bus Stop	Economy	$89	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/10/2026 12:10:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/11/2026 7:00:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 18h 50m

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	16h 5m	2:55 PM	Florence, SC	Bus Station	7:00 AM	Jacksonville, FL	Downtown Bus Stop		Economy	$83	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/11/2026 2:55:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/12/2026 7:00:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 16h 5m
	Greyhound US	18h 50m	12:10 PM	Florence, SC	Bus Station	7:00 AM	Jacksonville, FL	Downtown Bus Stop		Economy	$90	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/11/2026 12:10:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/12/2026 7:00:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 18h 50m

Did you know that if you travel from Florence, SC to Jacksonville, FL via Atlanta, GA, you can save more than $9? You can find the corresponding connections below.
- Greyhound US
  
  22h 40m
  
  0
  
  2:55 PM
  
  Florence, SC
  Bus Station
  
  9:35 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $36
  
  A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/11/2026 2:55:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 9/11/2026 9:35:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 6h 40m
- FlixBus
  
  6h 35m
  
  0
  
  7:00 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  1:35 PM
  
  Jacksonville, FL
  Downtown Bus Stop
  
  0
  
  Economy
  
  $38
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 9/12/2026 7:00:00 AM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/12/2026 1:35:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 35m
Travel time is 6h 35m longer, but you will save $9

Cheapest bus trips Saturday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	5h 45m	5:45 AM	Florence, SC	TA Travel Center	11:30 AM	Jacksonville, FL	Amtrak Train Station		Economy	$52	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/12/2026 5:45:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 9/12/2026 11:30:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 5h 45m

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	16h 5m	2:55 PM	Florence, SC	Bus Station	7:00 AM	Jacksonville, FL	Downtown Bus Stop		Economy	$82	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/13/2026 2:55:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/14/2026 7:00:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 16h 5m
	Greyhound US	18h 50m	12:10 PM	Florence, SC	Bus Station	7:00 AM	Jacksonville, FL	Downtown Bus Stop		Economy	$89	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/13/2026 12:10:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/14/2026 7:00:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 18h 50m

Did you know that if you travel from Florence, SC to Jacksonville, FL via Atlanta, GA, you can save more than $8? You can find the corresponding connections below.
- Greyhound US
  
  22h 40m
  
  0
  
  2:55 PM
  
  Florence, SC
  Bus Station
  
  9:35 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $36
  
  A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/11/2026 2:55:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 9/11/2026 9:35:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 6h 40m
- FlixBus
  
  6h 35m
  
  0
  
  7:00 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  1:35 PM
  
  Jacksonville, FL
  Downtown Bus Stop
  
  0
  
  Economy
  
  $38
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 9/12/2026 7:00:00 AM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/12/2026 1:35:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 35m
Travel time is 6h 35m longer, but you will save $8

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 45m	5:45 AM	Florence, SC	TA Travel Center	11:30 AM	Jacksonville, FL	Amtrak Train Station	Economy	$44	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/14/2026 5:45:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 9/14/2026 11:30:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 5h 45m
Greyhound US	16h 5m	2:55 PM	Florence, SC	Bus Station	7:00 AM	Jacksonville, FL	Downtown Bus Stop	Economy	$82	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/14/2026 2:55:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/15/2026 7:00:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 16h 5m
Greyhound US	18h 50m	12:10 PM	Florence, SC	Bus Station	7:00 AM	Jacksonville, FL	Downtown Bus Stop	Economy	$89	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/14/2026 12:10:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 9/15/2026 7:00:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 18h 50m

Best Price Offer: The price for the cheapest bus from Florence, SC to Jacksonville, FL is $40 on 9/14/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Florence, SC and Jacksonville, FL

See here how frequent the connections between Florence, SC and Jacksonville, FL are, during different times and days of the week.

Monday is the busiest day, with more than 3 daily buses from Florence, SC to Jacksonville, FL. Saturday has instead the fewest connections, with only 1 daily coaches between Florence, SC and Jacksonville, FL.

The busiest time of the day is the Afternoon, with 10 buses from Florence, SC to Jacksonville, FL, while Night sees the fewest connections between Florence, SC and Jacksonville, FL, with 4 offers.

Facts about the bus from Florence, SC to Jacksonville, FL

Compare all providers like Greyhound US and FlixBus that travel 2 times every day by bus from Florence, SC to Jacksonville, FL in one click! Book your bus ticket from Florence, SC to Jacksonville, FL starting from $40!

Cheapest Bus	$40
Fastest Bus	5h 45m
Earliest Bus	5:45 AM
Latest Bus	2:55 PM
Daily Bus Routes	2 Ø
Distance	289.6 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Florence, SC to Jacksonville, FL

Every day, 2 buses from 2 bus companies leave Florence, SC for Jacksonville, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/09/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/06

Monday 09/07

Tuesday 09/08

Wednesday 09/09

$51

Thursday 09/10

$47

Friday 09/11

$48

Saturday 09/12

$52

Sunday 09/13

$47

Monday 09/14

$40

Tuesday 09/15

Wednesday 09/16

$82

Thursday 09/17

$44

Friday 09/18

$48

Saturday 09/19

Sunday 09/20

Monday 09/21

Tuesday 09/22

Wednesday 09/23

Thursday 09/24

Friday 09/25

Saturday 09/26

Sunday 09/27

Monday 09/28

$45

Tuesday 09/29

$91

Wednesday 09/30

$89

Thursday 10/01

$45

Friday 10/02

$54

Saturday 10/03

The cheapest time to travel from Florence, SC to Jacksonville, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Florence, SC to Jacksonville, FL, for the next 30 days.

With a price starting from $40, Monday is the cheapest day for a bus from Florence, SC to Jacksonville, FL. Saturday instead is the most expensive day with prices starting from $51.

Night is the cheapest day time for bus tickets from Florence, SC to Jacksonville, FL, with $40. Afternoon is the most expensive time of the day with prices starting from $81.

How to save money travelling from Florence, SC to Jacksonville, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Jacksonville, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Jacksonville, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Jacksonville, FL are also emptier.

Beloved bus companies from Florence, SC to Jacksonville, FL

These are the most booked bus companies between Florence, SC to Jacksonville, FL from our users.

FlixBus from Florence, SC to Jacksonville, FL

Here you will find the key facts about the FlixBus bus route Florence, SC to Jacksonville, FL:

Cheapest Price	$44
Fastest Bus	5h 45m
Earliest Bus	5:45 AM
Last Bus	5:45 AM
Daily Connections	1 Ø
Found on	8/15/2026

All bus stations and stops in Florence, SC and Jacksonville, FL

In the map below, you can see where to find all bus stations in Florence, SC and Jacksonville, FL.

Bus Station

S Irby St 611

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

South Carolina Federal Gas Station

Downtown Bus Stop

West Forsyth Street 1111

Beaver St. & Ocean St. Bus Stop

Central Bus Station

Old St. Augustine Rd

Old St. Augustine Rd 10584-13

Southpoint Bus Stop

Service and Comfort on the bus from Florence, SC to Jacksonville, FL

Want to know which seat classes are available on the buses from Florence, SC to Jacksonville, FL? Or which bus companies serve the route Florence, SC to Jacksonville, FL? Below you will find answers to your questions.

FAQs about the Florence, SC to Jacksonville, FL bus

How much does a Florence, SC Jacksonville, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $40 and takes 5h 45m to reach Jacksonville, FL. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Jacksonville, FL?

This route is offered by 2 companies with a range of ticket prices between $40 and $90. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Jacksonville, FL.

On average, how many connections are available from Florence, SC to Jacksonville, FL each day?

Every day, the Florence, SC to Jacksonville, FL bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Jacksonville, FL take?

The fastest bus from Florence, SC to Jacksonville, FL is offered by FlixBus and takes 5h 45m. Bus tickets for this connection cost $51. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Jacksonville, FL?

The earliest bus arriving in Jacksonville, FL from Florence, SC starts at 5:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Jacksonville, FL?

The latest bus trip departing from Florence, SC for Jacksonville, FL starts at 2:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Jacksonville, FL route?

When traveling by bus from Florence, SC to Jacksonville, FL, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Jacksonville, FL?

You can check all the direct connections between Florence, SC and Jacksonville, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Florence, SC to Jacksonville, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Jacksonville, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Jacksonville, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Jacksonville, FL on your planned travel date.

How does CheckMyBus find the best bus deals from Florence, SC to Jacksonville, FL?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Florence, SC and Jacksonville, FL. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Florence, SC to Jacksonville, FL?

Prices and availability for 2 trips between Florence, SC and Jacksonville, FL change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Florence, SC to Jacksonville, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Jacksonville, FL

Here’s an overview of the most popular bus routes to Florence, SC and to Jacksonville, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!