Bus Cambridge, MA to Florence, SC - Compare all Companies

Compare all timetables for the bus from Cambridge, MA to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Cambridge, MA to Florence, SC from various bus operators like FlixBus for the next days.

today

$118

tomorrow

$116

Monday

$97

Tuesday

$108

Wednesday

$112

Thursday

Friday

$114

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	22h 10m	11:00 AM	Cambridge, MA	Alewife Station	9:10 AM	Florence, SC	Bus Station		Economy	$118	A Bus from FlixBus goes from Alewife Station, Cambridge, MA (USA) at 7/25/2026 11:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/26/2026 9:10:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 22h 10m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	22h 10m	11:00 AM	Cambridge, MA	Alewife Station	9:10 AM	Florence, SC	Bus Station		Economy	$116	A Bus from FlixBus goes from Alewife Station, Cambridge, MA (USA) at 7/26/2026 11:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/27/2026 9:10:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 22h 10m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	22h 10m	11:00 AM	Cambridge, MA	Alewife Station	9:10 AM	Florence, SC	Bus Station		Economy	$97	A Bus from FlixBus goes from Alewife Station, Cambridge, MA (USA) at 7/27/2026 11:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/28/2026 9:10:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 22h 10m

Cheapest bus trips Tuesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	37h 5m	11:00 AM	Cambridge, MA	Alewife Station	12:05 AM	Florence, SC	TA Travel Center		Economy	$108	A Bus from FlixBus goes from Alewife Station, Cambridge, MA (USA) at 7/28/2026 11:00:00 AM to TA Travel Center, Florence, SC (USA) arriving at 7/30/2026 12:05:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 37h 5m
	FlixBus	22h 10m	11:00 AM	Cambridge, MA	Alewife Station	9:10 AM	Florence, SC	Bus Station		Economy	$108	A Bus from FlixBus goes from Alewife Station, Cambridge, MA (USA) at 7/28/2026 11:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/29/2026 9:10:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 22h 10m

Cheapest bus trips Wednesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	37h 5m	11:00 AM	Cambridge, MA	Alewife Station	12:05 AM	Florence, SC	TA Travel Center		Economy	$112	A Bus from FlixBus goes from Alewife Station, Cambridge, MA (USA) at 7/29/2026 11:00:00 AM to TA Travel Center, Florence, SC (USA) arriving at 7/31/2026 12:05:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 37h 5m
	FlixBus	22h 10m	11:00 AM	Cambridge, MA	Alewife Station	9:10 AM	Florence, SC	Bus Station		Economy	$112	A Bus from FlixBus goes from Alewife Station, Cambridge, MA (USA) at 7/29/2026 11:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/30/2026 9:10:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 22h 10m

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	22h 10m	11:00 AM	Cambridge, MA	Alewife Station	9:10 AM	Florence, SC	Bus Station		Economy	$114	A Bus from FlixBus goes from Alewife Station, Cambridge, MA (USA) at 7/31/2026 11:00:00 AM to Bus Station, Florence, SC (USA) arriving at 8/1/2026 9:10:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 22h 10m

Did you know that if you travel from Cambridge, MA to Florence, SC via Baltimore, MD, you can save more than $11? You can find the corresponding connections below.
- FlixBus
  
  24h 45m
  
  0
  
  11:00 AM
  
  Cambridge, MA
  Alewife Station
  
  11:55 PM
  
  Baltimore, MD
  Downtown Bus Station
  
  0
  
  Economy
  
  $48
  
  A Bus from FlixBus goes from Alewife Station, Cambridge, MA (USA) at 7/28/2026 11:00:00 AM to Downtown Bus Station, Baltimore, MD (USA) arriving at 7/28/2026 11:55:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 12h 55m
- FlixBus
  
  10h 10m
  
  0
  
  1:35 AM
  
  Baltimore, MD
  Downtown Bus Station
  
  11:45 AM
  
  Florence, SC
  Bus Station
  
  0
  
  Economy
  
  $55
  
  A Bus from FlixBus goes from Downtown Bus Station, Baltimore, MD (USA) at 7/29/2026 1:35:00 AM to Bus Station, Florence, SC (USA) arriving at 7/29/2026 11:45:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 10h 10m
Travel time is 2h 35m longer, but you will save $11

Best Price Offer: The price for the cheapest bus from Cambridge, MA to Florence, SC is $86 on 8/12/2026. Flexible travelers save on ticket prices.

Facts about the bus from Cambridge, MA to Florence, SC

Compare all providers like FlixBus that travel 1 times every day by bus from Cambridge, MA to Florence, SC in one click! Book your bus ticket from Cambridge, MA to Florence, SC starting from $86!

Cheapest Bus	$86
Fastest Bus	22h 10m
Earliest Bus	11:00 AM
Latest Bus	11:00 AM
Daily Bus Routes	1 Ø
Distance	733.9 miles
Bus Companies	FlixBus

Cheapest bus connections from Cambridge, MA to Florence, SC

Every day, 1 buses from 1 bus companies leave Cambridge, MA for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

$118

Sunday 07/26

$116

Monday 07/27

$97

Tuesday 07/28

$108

Wednesday 07/29

$112

Thursday 07/30

Friday 07/31

$114

Saturday 08/01

Sunday 08/02

Monday 08/03

Tuesday 08/04

$105

Wednesday 08/05

$102

Thursday 08/06

Friday 08/07

$108

Saturday 08/08

$110

Sunday 08/09

$102

Monday 08/10

$98

Tuesday 08/11

$102

Wednesday 08/12

$86

Thursday 08/13

Friday 08/14

$100

Saturday 08/15

How to save money travelling from Cambridge, MA to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Cambridge, MA to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Cambridge, MA to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Cambridge, MA to Florence, SC are also emptier.

All bus stations and stops in Cambridge, MA and Florence, SC

In the map below, you can see where to find all bus stations in Cambridge, MA and Florence, SC.

Alewife Station

Rindge Ave 351

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Service and Comfort on the bus from Cambridge, MA to Florence, SC

Want to know which seat classes are available on the buses from Cambridge, MA to Florence, SC? Or which bus companies serve the route Cambridge, MA to Florence, SC? Below you will find answers to your questions.

FAQs about the Cambridge, MA to Florence, SC bus

How much does a Cambridge, MA Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $86 and takes 22h 10m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Cambridge, MA to Florence, SC?

This route is offered by 1 companies with a range of ticket prices between $86 and $120. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Cambridge, MA to Florence, SC each day?

Every day, the Cambridge, MA to Florence, SC bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Cambridge, MA to Florence, SC take?

The fastest bus from Cambridge, MA to Florence, SC is offered by FlixBus and takes 22h 10m. Bus tickets for this connection cost $118. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Cambridge, MA to Florence, SC?

The earliest bus arriving in Florence, SC from Cambridge, MA starts at 11:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Cambridge, MA to Florence, SC?

The latest bus trip departing from Cambridge, MA for Florence, SC starts at 11:00 AM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Cambridge, MA Florence, SC route?

When traveling by bus from Cambridge, MA to Florence, SC, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Cambridge, MA and Florence, SC?

You can check all the direct connections between Cambridge, MA and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Cambridge, MA to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Cambridge, MA Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Cambridge, MA Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Cambridge, MA to Florence, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Cambridge, MA to Florence, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 1 daily trips between Cambridge, MA and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Cambridge, MA to Florence, SC?

Prices and availability for 1 trips between Cambridge, MA and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Cambridge, MA to Florence, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Cambridge, MA and to Florence, SC

Here’s an overview of the most popular bus routes to Cambridge, MA and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!