Bus Florence, SC to Chicago: Compare prices and save money

Compare all timetables for the bus from Florence, SC to Chicago

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Chicago from various bus operators like Greyhound US or FlixBus for the next days.

today

$100

tomorrow

$105

Friday

$123

Saturday

$101

Sunday

Monday

$94

Tuesday

$84

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	27h 15m	5:45 AM	Florence, SC	TA Travel Center	8:00 AM	Chicago	Union Station	Economy	$100	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/9/2026 5:45:00 AM to Union Station, Chicago (USA) arriving at 9/10/2026 8:00:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 27h 15m
FlixBus	27h 40m	5:45 AM	Florence, SC	TA Travel Center	8:25 AM	Chicago	Downtown Bus Station	Economy	$100	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/9/2026 5:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 9/10/2026 8:25:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 27h 40m
FlixBus	29h 5m	5:45 AM	Florence, SC	TA Travel Center	9:50 AM	Chicago	95th Red Line Station	Economy	$111	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/9/2026 5:45:00 AM to 95th Red Line Station, Chicago (USA) arriving at 9/10/2026 9:50:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 29h 5m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	29h 5m	5:45 AM	Florence, SC	TA Travel Center	9:50 AM	Chicago	95th Red Line Station		Economy	$105	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/10/2026 5:45:00 AM to 95th Red Line Station, Chicago (USA) arriving at 9/11/2026 9:50:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 29h 5m
	FlixBus	30h 35m	12:05 AM	Florence, SC	TA Travel Center	5:40 AM	Chicago	95th Red Line Station		Economy	$119	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/10/2026 12:05:00 AM to 95th Red Line Station, Chicago (USA) arriving at 9/11/2026 5:40:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 30h 35m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	31h 5m	12:05 AM	Florence, SC	TA Travel Center	6:10 AM	Chicago	Downtown Bus Station	Economy	$123	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/11/2026 12:05:00 AM to Downtown Bus Station, Chicago (USA) arriving at 9/12/2026 6:10:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 31h 5m
FlixBus	27h 40m	5:45 AM	Florence, SC	TA Travel Center	8:25 AM	Chicago	Downtown Bus Station	Economy	$126	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/11/2026 5:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 9/12/2026 8:25:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 27h 40m
FlixBus	27h 15m	5:45 AM	Florence, SC	TA Travel Center	8:00 AM	Chicago	Union Station	Economy	$126	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/11/2026 5:45:00 AM to Union Station, Chicago (USA) arriving at 9/12/2026 8:00:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 27h 15m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 55m	12:10 PM	Florence, SC	Bus Station	11:05 AM	Chicago	95th Red Line Station	Economy	$101	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/12/2026 12:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 9/13/2026 11:05:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 23h 55m
Greyhound US	28h 30m	2:55 PM	Florence, SC	Bus Station	6:25 PM	Chicago	95th Red Line Station	Economy	$102	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/12/2026 2:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 9/13/2026 6:25:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 28h 30m
Greyhound US	29h 35m	7:20 PM	Florence, SC	Bus Station	11:55 PM	Chicago	95th Red Line Station	Economy	$102	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/12/2026 7:20:00 PM to 95th Red Line Station, Chicago (USA) arriving at 9/13/2026 11:55:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 29h 35m
FlixBus	29h 5m	5:45 AM	Florence, SC	TA Travel Center	9:50 AM	Chicago	95th Red Line Station	Economy	$109	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/12/2026 5:45:00 AM to 95th Red Line Station, Chicago (USA) arriving at 9/13/2026 9:50:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 29h 5m
FlixBus	30h 35m	12:05 AM	Florence, SC	TA Travel Center	5:40 AM	Chicago	95th Red Line Station	Economy	$113	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/12/2026 12:05:00 AM to 95th Red Line Station, Chicago (USA) arriving at 9/13/2026 5:40:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 30h 35m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 55m	12:10 PM	Florence, SC	Bus Station	11:05 AM	Chicago	95th Red Line Station	Economy	$94	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/14/2026 12:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 9/15/2026 11:05:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 23h 55m
Greyhound US	29h 50m	3:20 PM	Florence, SC	Bus Station	8:10 PM	Chicago	Downtown Bus Station	Economy	$94	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/14/2026 3:20:00 PM to Downtown Bus Station, Chicago (USA) arriving at 9/15/2026 8:10:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 29h 50m
FlixBus	27h 40m	5:45 AM	Florence, SC	TA Travel Center	8:25 AM	Chicago	Downtown Bus Station	Economy	$95	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/14/2026 5:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 9/15/2026 8:25:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 27h 40m
FlixBus	27h 15m	5:45 AM	Florence, SC	TA Travel Center	8:00 AM	Chicago	Union Station	Economy	$95	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/14/2026 5:45:00 AM to Union Station, Chicago (USA) arriving at 9/15/2026 8:00:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 27h 15m
Greyhound US	28h 30m	2:55 PM	Florence, SC	Bus Station	6:25 PM	Chicago	95th Red Line Station	Economy	$95	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/14/2026 2:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 9/15/2026 6:25:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 28h 30m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	25h 20m	2:55 PM	Florence, SC	Bus Station	3:15 PM	Chicago	Downtown Bus Station	Economy	$84	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/15/2026 2:55:00 PM to Downtown Bus Station, Chicago (USA) arriving at 9/16/2026 3:15:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 25h 20m
Greyhound US	29h 35m	7:20 PM	Florence, SC	Bus Station	11:55 PM	Chicago	95th Red Line Station	Economy	$85	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/15/2026 7:20:00 PM to 95th Red Line Station, Chicago (USA) arriving at 9/16/2026 11:55:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 29h 35m
Greyhound US	28h 30m	2:55 PM	Florence, SC	Bus Station	6:25 PM	Chicago	95th Red Line Station	Economy	$86	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/15/2026 2:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 9/16/2026 6:25:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 28h 30m
FlixBus	34h 45m	12:05 AM	Florence, SC	TA Travel Center	9:50 AM	Chicago	95th Red Line Station	Economy	$110	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/15/2026 12:05:00 AM to 95th Red Line Station, Chicago (USA) arriving at 9/16/2026 9:50:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 34h 45m

Best Price Offer: The price for the cheapest bus from Florence, SC to Chicago is $81 on 9/17/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Florence, SC and Chicago

See here how frequent the connections between Florence, SC and Chicago are, during different times and days of the week.

Monday is the busiest day, with more than 23 daily buses from Florence, SC to Chicago. Thursday has instead the fewest connections, with only 2 daily coaches between Florence, SC and Chicago.

The busiest time of the day is the Afternoon, with 30 buses from Florence, SC to Chicago, while Evening sees the fewest connections between Florence, SC and Chicago, with 15 offers.

Facts about the bus from Florence, SC to Chicago

Compare all providers like Greyhound US and FlixBus that travel 10 times every day by bus from Florence, SC to Chicago in one click! Book your bus ticket from Florence, SC to Chicago starting from $81!

Cheapest Bus	$81
Fastest Bus	22h 55m
Earliest Bus	5:45 AM
Latest Bus	7:20 PM
Daily Bus Routes	10 Ø
Distance	681.8 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Florence, SC to Chicago

Every day, 10 buses from 2 bus companies leave Florence, SC for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/09/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/06

Monday 09/07

Tuesday 09/08

Wednesday 09/09

$111

Thursday 09/10

$105

Friday 09/11

$123

Saturday 09/12

$101

Sunday 09/13

Monday 09/14

$95

Tuesday 09/15

$84

Wednesday 09/16

Thursday 09/17

$81

Friday 09/18

$111

Saturday 09/19

$111

Sunday 09/20

Monday 09/21

Tuesday 09/22

Wednesday 09/23

$82

Thursday 09/24

$125

Friday 09/25

$96

Saturday 09/26

Sunday 09/27

$124

Monday 09/28

$87

Tuesday 09/29

$108

Wednesday 09/30

Thursday 10/01

$111

Friday 10/02

$104

Saturday 10/03

The cheapest time to travel from Florence, SC to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from Florence, SC to Chicago, for the next 30 days.

With a price starting from $81, Thursday is the cheapest day for a bus from Florence, SC to Chicago. Saturday instead is the most expensive day with prices starting from $101.

Night is the cheapest day time for bus tickets from Florence, SC to Chicago, with $81. Evening is the most expensive time of the day with prices starting from $85.

How to save money travelling from Florence, SC to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Chicago are also emptier.

All bus stations and stops in Florence, SC and Chicago

In the map below, you can see where to find all bus stations in Florence, SC and Chicago.

Bus Station

S Irby St 611

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

South Carolina Federal Gas Station

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from Florence, SC to Chicago

Want to know which seat classes are available on the buses from Florence, SC to Chicago? Or which bus companies serve the route Florence, SC to Chicago? Below you will find answers to your questions.

FAQs about the Florence, SC to Chicago bus

How much does a Florence, SC Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $81 and takes 24h 20m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Chicago?

This route is offered by 2 companies with a range of ticket prices between $81 and $150. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Florence, SC to Chicago each day?

Every day, the Florence, SC to Chicago bus route is served by approximately 10 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Chicago take?

The fastest bus from Florence, SC to Chicago is offered by Greyhound US and takes 22h 55m. Bus tickets for this connection cost $101. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Chicago?

The earliest bus arriving in Chicago from Florence, SC starts at 5:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Chicago?

The latest bus trip departing from Florence, SC for Chicago starts at 7:20 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Chicago route?

When traveling by bus from Florence, SC to Chicago, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Chicago?

You can check all the direct connections between Florence, SC and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Florence, SC to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Florence, SC to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 10 daily trips between Florence, SC and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Florence, SC to Chicago?

Prices and availability for 10 trips between Florence, SC and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Florence, SC to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Chicago

Here’s an overview of the most popular bus routes to Florence, SC and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!