Bus Chicago to San Diego - Compare all Companies

Compare all timetables for the bus from Chicago to San Diego

Here is a selection of the cheapest bus trips from the schedule from Chicago to San Diego from various bus operators like Greyhound US or FlixBus for the next days.

today

$160

tomorrow

$131

Saturday

$134

Sunday

$121

Monday

$131

Tuesday

$126

Wednesday

$146

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	55h 55m	12:25 PM	Chicago	Downtown Bus Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$160	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/10/2026 12:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 9/12/2026 6:20:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 55h 55m
Greyhound US	69h 30m	10:50 PM	Chicago	Downtown Bus Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$180	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/10/2026 10:50:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 9/13/2026 6:20:00 PM. 50 Economy ticket for $180 per person are available. Travel duration is 69h 30m
Greyhound US	69h 10m	11:10 PM	Chicago	Canal & Van Buren	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$180	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 9/10/2026 11:10:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 9/13/2026 6:20:00 PM. 50 Economy ticket for $180 per person are available. Travel duration is 69h 10m
FlixBus	57h 15m	11:05 AM	Chicago	95th Red Line Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$219	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/10/2026 11:05:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 9/12/2026 6:20:00 PM. 50 Economy ticket for $219 per person are available. Travel duration is 57h 15m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	55h 20m	11:05 AM	Chicago	95th Red Line Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$131	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/11/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 9/13/2026 4:25:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 55h 20m
Greyhound US	54h 25m	1:20 PM	Chicago	95th Red Line Station	5:45 PM	San Diego	Old Town Transit Center	Economy	$134	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 9/11/2026 1:20:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/13/2026 5:45:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 54h 25m
Greyhound US	58h 55m	1:20 PM	Chicago	95th Red Line Station	10:15 PM	San Diego	Seaport Village	Economy	$135	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 9/11/2026 1:20:00 PM to Seaport Village, San Diego (USA) arriving at 9/13/2026 10:15:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 58h 55m
Greyhound US	54h 50m	1:20 PM	Chicago	95th Red Line Station	6:10 PM	San Diego	Old Town Transit Center	Economy	$135	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 9/11/2026 1:20:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/13/2026 6:10:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 54h 50m
FlixBus	55h 0m	5:15 PM	Chicago	Downtown Bus Station	10:15 PM	San Diego	Seaport Village	Economy	$139	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 9/11/2026 5:15:00 PM to Seaport Village, San Diego (USA) arriving at 9/13/2026 10:15:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 55h 0m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	66h 30m	11:55 PM	Chicago	95th Red Line Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$134	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/12/2026 11:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/15/2026 4:25:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 66h 30m
FlixBus	55h 20m	11:05 AM	Chicago	95th Red Line Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$135	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/12/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 9/14/2026 4:25:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 55h 20m
Greyhound US	62h 0m	11:45 PM	Chicago	95th Red Line Station	11:45 AM	San Diego	Old Town Transit Center	Economy	$145	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 9/12/2026 11:45:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/15/2026 11:45:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 62h 0m
FlixBus	61h 5m	12:40 AM	Chicago	95th Red Line Station	11:45 AM	San Diego	Old Town Transit Center	Economy	$153	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/12/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 9/14/2026 11:45:00 AM. 50 Economy ticket for $153 per person are available. Travel duration is 61h 5m
Greyhound US	54h 0m	12:25 PM	Chicago	Downtown Bus Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$156	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/12/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/14/2026 4:25:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 54h 0m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	66h 30m	11:55 PM	Chicago	95th Red Line Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$121	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/13/2026 11:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/16/2026 4:25:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 66h 30m
FlixBus	55h 20m	11:05 AM	Chicago	95th Red Line Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$122	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/13/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 9/15/2026 4:25:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 55h 20m
FlixBus	61h 5m	12:40 AM	Chicago	95th Red Line Station	11:45 AM	San Diego	Old Town Transit Center	Economy	$123	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/13/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 9/15/2026 11:45:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 61h 5m
Greyhound US	55h 55m	12:25 PM	Chicago	Downtown Bus Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$140	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/13/2026 12:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 9/15/2026 6:20:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 55h 55m
Greyhound US	54h 0m	12:25 PM	Chicago	Downtown Bus Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$147	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/13/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/15/2026 4:25:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 54h 0m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	55h 20m	11:05 AM	Chicago	95th Red Line Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$131	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/14/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 9/16/2026 4:25:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 55h 20m
FlixBus	66h 30m	11:55 PM	Chicago	95th Red Line Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$131	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/14/2026 11:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/17/2026 4:25:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 66h 30m
FlixBus	61h 5m	12:40 AM	Chicago	95th Red Line Station	11:45 AM	San Diego	Old Town Transit Center	Economy	$137	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/14/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 9/16/2026 11:45:00 AM. 50 Economy ticket for $137 per person are available. Travel duration is 61h 5m
Greyhound US	58h 5m	10:15 AM	Chicago	Union Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$148	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 9/14/2026 10:15:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 9/16/2026 6:20:00 PM. 50 Economy ticket for $148 per person are available. Travel duration is 58h 5m
Greyhound US	54h 0m	12:25 PM	Chicago	Downtown Bus Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$149	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/14/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/16/2026 4:25:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 54h 0m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	55h 20m	11:05 AM	Chicago	95th Red Line Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$126	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/15/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 9/17/2026 4:25:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 55h 20m
FlixBus	66h 30m	11:55 PM	Chicago	95th Red Line Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$127	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/15/2026 11:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/18/2026 4:25:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 66h 30m
Greyhound US	55h 55m	12:25 PM	Chicago	Downtown Bus Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$138	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/15/2026 12:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 9/17/2026 6:20:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 55h 55m
Greyhound US	58h 55m	1:20 PM	Chicago	95th Red Line Station	10:15 PM	San Diego	Seaport Village	Economy	$140	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 9/15/2026 1:20:00 PM to Seaport Village, San Diego (USA) arriving at 9/17/2026 10:15:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 58h 55m
Greyhound US	58h 5m	10:15 AM	Chicago	Union Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$141	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 9/15/2026 10:15:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 9/17/2026 6:20:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 58h 5m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	54h 0m	12:25 PM	Chicago	Downtown Bus Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$146	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/16/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/18/2026 4:25:00 PM. 50 Economy ticket for $146 per person are available. Travel duration is 54h 0m
Greyhound US	53h 30m	12:25 PM	Chicago	Downtown Bus Station	3:55 PM	San Diego	La Jolla Village	Economy	$146	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/16/2026 12:25:00 PM to La Jolla Village, San Diego (USA) arriving at 9/18/2026 3:55:00 PM. 50 Economy ticket for $146 per person are available. Travel duration is 53h 30m
Greyhound US	61h 55m	10:30 PM	Chicago	Downtown Bus Station	10:25 AM	San Diego	Seaport Village	Economy	$158	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/16/2026 10:30:00 PM to Seaport Village, San Diego (USA) arriving at 9/19/2026 10:25:00 AM. 50 Economy ticket for $158 per person are available. Travel duration is 61h 55m
FlixBus	66h 5m	6:00 PM	Chicago	Downtown Bus Station	10:05 AM	San Diego	Old Town Transit Center	Economy	$174	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 9/16/2026 6:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/19/2026 10:05:00 AM. 50 Economy ticket for $174 per person are available. Travel duration is 66h 5m

Best Price Offer: The price for the cheapest bus from Chicago to San Diego is $121 on 9/13/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and San Diego

See here how frequent the connections between Chicago and San Diego are, during different times and days of the week.

Friday is the busiest day, with more than 30 daily buses from Chicago to San Diego. Thursday has instead the fewest connections, with only 5 daily coaches between Chicago and San Diego.

The busiest time of the day is the Afternoon, with 41 buses from Chicago to San Diego, while Night sees the fewest connections between Chicago and San Diego, with 6 offers.

Facts about the bus from Chicago to San Diego

Compare all providers like Greyhound US and FlixBus that travel 17 times every day by bus from Chicago to San Diego in one click! Book your bus ticket from Chicago to San Diego starting from $121!

Cheapest Bus	$121
Fastest Bus	48h 30m
Earliest Bus	11:05 AM
Latest Bus	11:10 PM
Daily Bus Routes	17 Ø
Distance	1,730.9 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Chicago to San Diego

Every day, 17 buses from 2 bus companies leave Chicago for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/10/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/06

Monday 09/07

Tuesday 09/08

Wednesday 09/09

Thursday 09/10

$160

Friday 09/11

$167

Saturday 09/12

$134

Sunday 09/13

$140

Monday 09/14

$131

Tuesday 09/15

$138

Wednesday 09/16

$146

Thursday 09/17

$192

Friday 09/18

$200

Saturday 09/19

$210

Sunday 09/20

$145

Monday 09/21

$189

Tuesday 09/22

$161

Wednesday 09/23

$187

Thursday 09/24

Friday 09/25

$181

Saturday 09/26

$131

Sunday 09/27

$156

Monday 09/28

$166

Tuesday 09/29

$176

Wednesday 09/30

$193

Thursday 10/01

$188

Friday 10/02

$149

Saturday 10/03

The cheapest time to travel from Chicago to San Diego

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to San Diego, for the next 30 days.

With a price starting from $121, Sunday is the cheapest day for a bus from Chicago to San Diego. Thursday instead is the most expensive day with prices starting from $160.

Evening is the cheapest day time for bus tickets from Chicago to San Diego, with $121. Afternoon is the most expensive time of the day with prices starting from $134.

How to save money travelling from Chicago to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to San Diego are also emptier.

Beloved bus companies from Chicago to San Diego

These are the most booked bus companies between Chicago to San Diego from our users.

FlixBus from Chicago to San Diego

Here you will find the key facts about the FlixBus bus route Chicago to San Diego:

Cheapest Price	$121
Fastest Bus	48h 30m
Earliest Bus	11:05 AM
Last Bus	6:00 PM
Daily Connections	4 Ø
Found on	8/17/2026

Greyhound US from Chicago to San Diego

Here you will find the key facts about the Greyhound US bus route Chicago to San Diego:

Cheapest Price	$134
Fastest Bus	51h 0m
Earliest Bus	12:25 PM
Last Bus	11:10 PM
Daily Connections	12 Ø
Found on	8/17/2026

All bus stations and stops in Chicago and San Diego

In the map below, you can see where to find all bus stations in Chicago and San Diego.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

Downtown

Service and Comfort on the bus from Chicago to San Diego

Want to know which seat classes are available on the buses from Chicago to San Diego? Or which bus companies serve the route Chicago to San Diego? Below you will find answers to your questions.

FAQs about the Chicago to San Diego bus

How much does a Chicago San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $121 and takes 64h 30m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Chicago to San Diego?

This route is offered by 2 companies with a range of ticket prices between $121 and $266. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Chicago to San Diego each day?

Every day, the Chicago to San Diego bus route is served by approximately 17 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to San Diego take?

The fastest bus from Chicago to San Diego is offered by FlixBus and takes 48h 30m. Bus tickets for this connection cost $139. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to San Diego?

The earliest bus arriving in San Diego from Chicago starts at 11:05 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to San Diego?

The latest bus trip departing from Chicago for San Diego starts at 11:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago San Diego route?

When traveling by bus from Chicago to San Diego, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and San Diego?

You can check all the direct connections between Chicago and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to San Diego on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to San Diego?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 17 daily trips between Chicago and San Diego. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to San Diego?

Prices and availability for 17 trips between Chicago and San Diego change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to San Diego

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to San Diego

Here’s an overview of the most popular bus routes to Chicago and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!