Bus San Antonio, TX to Indianapolis: Compare prices and save money

Compare all timetables for the bus from San Antonio, TX to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to Indianapolis from various bus operators like FlixBus, Greyhound US or Greyhound Lines Mexico for the next days.

today

tomorrow

$125

Tuesday

$123

Wednesday

$126

Thursday

$123

Friday

Saturday

$139

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	26h 25m	1:30 AM	San Antonio, TX	Bus Station	4:55 AM	Indianapolis	Central Bus Station	Economy	$125	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 7/27/2026 1:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/28/2026 4:55:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 26h 25m
Greyhound Lines Mexico	29h 20m	5:50 AM	San Antonio, TX	Bus Station	12:10 PM	Indianapolis	Central Bus Station	Economy	$125	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 7/27/2026 5:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/28/2026 12:10:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 29h 20m
FlixBus	36h 55m	9:55 PM	San Antonio, TX	Bus Station	11:50 AM	Indianapolis	Washington / Delaware	Economy	$125	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 7/27/2026 9:55:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 7/29/2026 11:50:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 36h 55m
FlixBus	30h 0m	7:30 AM	San Antonio, TX	Bus Station	2:30 PM	Indianapolis	Central Bus Station	Economy	$125	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 7/27/2026 7:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/28/2026 2:30:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 30h 0m
Greyhound US	32h 10m	12:35 PM	San Antonio, TX	Bus Station	9:45 PM	Indianapolis	Washington / Delaware	Economy	$126	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/27/2026 12:35:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 7/28/2026 9:45:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 32h 10m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	32h 10m	12:35 PM	San Antonio, TX	Bus Station	9:45 PM	Indianapolis	Downtown Transit Center	Economy	$123	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/28/2026 12:35:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 7/29/2026 9:45:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 32h 10m
Greyhound US	27h 10m	12:35 PM	San Antonio, TX	Bus Station	4:45 PM	Indianapolis	Central Bus Station	Economy	$123	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/28/2026 12:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/29/2026 4:45:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 27h 10m
Greyhound US	29h 20m	5:50 AM	San Antonio, TX	Bus Station	12:10 PM	Indianapolis	Central Bus Station	Economy	$124	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/28/2026 5:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/29/2026 12:10:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 29h 20m
FlixBus	33h 5m	9:55 PM	San Antonio, TX	Bus Station	8:00 AM	Indianapolis	Downtown Transit Center	Economy	$127	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 7/28/2026 9:55:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 7/30/2026 8:00:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 33h 5m
FlixBus	30h 0m	9:55 PM	San Antonio, TX	Bus Station	4:55 AM	Indianapolis	Central Bus Station	Economy	$139	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 7/28/2026 9:55:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/30/2026 4:55:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 30h 0m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	32h 10m	12:35 PM	San Antonio, TX	Bus Station	9:45 PM	Indianapolis	Washington / Delaware	Economy	$126	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/29/2026 12:35:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 7/30/2026 9:45:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 32h 10m
Greyhound Lines Mexico	29h 20m	5:50 AM	San Antonio, TX	Bus Station	12:10 PM	Indianapolis	Central Bus Station	Economy	$127	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 7/29/2026 5:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/30/2026 12:10:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 29h 20m
Greyhound US	27h 10m	12:35 PM	San Antonio, TX	Bus Station	4:45 PM	Indianapolis	Central Bus Station	Economy	$127	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/29/2026 12:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/30/2026 4:45:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 27h 10m
Greyhound Lines Mexico	29h 30m	1:30 AM	San Antonio, TX	Bus Station	8:00 AM	Indianapolis	Washington / Delaware	Economy	$130	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 7/29/2026 1:30:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 7/30/2026 8:00:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 29h 30m
FlixBus	47h 15m	7:45 AM	San Antonio, TX	Pearl District	8:00 AM	Indianapolis	Washington / Delaware	Economy	$131	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 7/29/2026 7:45:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 7/31/2026 8:00:00 AM. 50 Economy ticket for $131 per person are available. Travel duration is 47h 15m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 10m	12:35 PM	San Antonio, TX	Bus Station	4:45 PM	Indianapolis	Central Bus Station	Economy	$123	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/30/2026 12:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/31/2026 4:45:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 27h 10m
Greyhound US	29h 20m	5:50 AM	San Antonio, TX	Bus Station	12:10 PM	Indianapolis	Central Bus Station	Economy	$126	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/30/2026 5:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/31/2026 12:10:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 29h 20m
Valley Transit	30h 55m	9:00 PM	San Antonio, TX	Bus Station	4:55 AM	Indianapolis	Central Bus Station	Economy	$133	A Bus from Valley Transit goes from Bus Station, San Antonio, TX (USA) at 7/30/2026 9:00:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/1/2026 4:55:00 AM. 50 Economy ticket for $133 per person are available. Travel duration is 30h 55m
Valley Transit	34h 0m	9:00 PM	San Antonio, TX	Bus Station	8:00 AM	Indianapolis	Downtown Transit Center	Economy	$133	A Bus from Valley Transit goes from Bus Station, San Antonio, TX (USA) at 7/30/2026 9:00:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 8/1/2026 8:00:00 AM. 50 Economy ticket for $133 per person are available. Travel duration is 34h 0m
FlixBus	30h 0m	7:30 AM	San Antonio, TX	Bus Station	2:30 PM	Indianapolis	Central Bus Station	Economy	$139	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 7/30/2026 7:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/31/2026 2:30:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 30h 0m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 10m	12:35 PM	San Antonio, TX	Bus Station	4:45 PM	Indianapolis	Central Bus Station	Economy	$139	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 8/1/2026 12:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/2/2026 4:45:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 27h 10m
Greyhound US	32h 10m	12:35 PM	San Antonio, TX	Bus Station	9:45 PM	Indianapolis	Downtown Transit Center	Economy	$139	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 8/1/2026 12:35:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 8/2/2026 9:45:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 32h 10m
Greyhound US	26h 25m	1:30 AM	San Antonio, TX	Bus Station	4:55 AM	Indianapolis	Central Bus Station	Economy	$140	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 8/1/2026 1:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 8/2/2026 4:55:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 26h 25m
FlixBus	45h 15m	9:45 AM	San Antonio, TX	Pearl District	8:00 AM	Indianapolis	Downtown Transit Center	Economy	$143	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 8/1/2026 9:45:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 8/3/2026 8:00:00 AM. 50 Economy ticket for $143 per person are available. Travel duration is 45h 15m
FlixBus	46h 45m	9:45 AM	San Antonio, TX	Pearl District	9:30 AM	Indianapolis	Central Bus Station	Economy	$145	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 8/1/2026 9:45:00 AM to Central Bus Station, Indianapolis (USA) arriving at 8/3/2026 9:30:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 46h 45m

Did you know that if you travel from San Antonio, TX to Indianapolis via Austin, you can save more than $21? You can find the corresponding connections below.
- Valley Transit
  
  34h 0m
  
  0
  
  9:00 PM
  
  San Antonio, TX
  Bus Station
  
  10:45 PM
  
  Austin
  5119 Eastside Bus Plaza
  
  0
  
  Economy
  
  $13
  
  A Bus from Valley Transit goes from Bus Station, San Antonio, TX (USA) at 7/31/2026 9:00:00 PM to 5119 Eastside Bus Plaza, Austin (USA) arriving at 7/31/2026 10:45:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 1h 45m
- FlixBus
  
  31h 30m
  
  0
  
  11:30 PM
  
  Austin
  5119 Eastside Bus Plaza
  
  8:00 AM
  
  Indianapolis
  Downtown Transit Center
  
  0
  
  Economy
  
  $105
  
  A Bus from FlixBus goes from 5119 Eastside Bus Plaza, Austin (USA) at 7/31/2026 11:30:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 8/2/2026 8:00:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 31h 30m
Travel time is 6h 35m longer, but you will save $21

Best Price Offer: The price for the cheapest bus from San Antonio, TX to Indianapolis is $116 on 8/13/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Antonio, TX and Indianapolis

See here how frequent the connections between San Antonio, TX and Indianapolis are, during different times and days of the week.

Thursday is the busiest day, with more than 18 daily buses from San Antonio, TX to Indianapolis. Tuesday has instead the fewest connections, with only 7 daily coaches between San Antonio, TX and Indianapolis.

The busiest time of the day is the Night, with 18 buses from San Antonio, TX to Indianapolis, while Afternoon sees the fewest connections between San Antonio, TX and Indianapolis, with 10 offers.

Facts about the bus from San Antonio, TX to Indianapolis

Compare all providers like FlixBus, Greyhound US and Greyhound Lines Mexico that travel 11 times every day by bus from San Antonio, TX to Indianapolis in one click! Book your bus ticket from San Antonio, TX to Indianapolis starting from $116!

Cheapest Bus	$116
Fastest Bus	27h 25m
Earliest Bus	1:30 AM
Latest Bus	9:55 PM
Daily Bus Routes	11 Ø
Distance	999.5 miles
Bus Companies	FlixBus, Greyhound US, Greyhound Lines Mexico and Valley Transit

Cheapest bus connections from San Antonio, TX to Indianapolis

Every day, 11 buses from 4 bus companies leave San Antonio, TX for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

Monday 07/27

$125

Tuesday 07/28

$123

Wednesday 07/29

$126

Thursday 07/30

$127

Friday 07/31

Saturday 08/01

$139

Sunday 08/02

$138

Monday 08/03

Tuesday 08/04

$121

Wednesday 08/05

Thursday 08/06

Friday 08/07

Saturday 08/08

$128

Sunday 08/09

$122

Monday 08/10

$127

Tuesday 08/11

$124

Wednesday 08/12

$125

Thursday 08/13

$116

Friday 08/14

Saturday 08/15

$117

Sunday 08/16

Monday 08/17

Tuesday 08/18

$128

Wednesday 08/19

Thursday 08/20

$125

Friday 08/21

$131

Saturday 08/22

The cheapest time to travel from San Antonio, TX to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to Indianapolis, for the next 30 days.

With a price starting from $116, Thursday is the cheapest day for a bus from San Antonio, TX to Indianapolis. Wednesday instead is the most expensive day with prices starting from $125.

Night is the cheapest day time for bus tickets from San Antonio, TX to Indianapolis, with $116. Evening is the most expensive time of the day with prices starting from $125.

How to save money travelling from San Antonio, TX to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to Indianapolis are also emptier.

Beloved bus companies from San Antonio, TX to Indianapolis

These are the most booked bus companies between San Antonio, TX to Indianapolis from our users.

FlixBus from San Antonio, TX to Indianapolis

Here you will find the key facts about the FlixBus bus route San Antonio, TX to Indianapolis:

Cheapest Price	$125
Fastest Bus	30h 45m
Earliest Bus	7:30 AM
Last Bus	9:55 PM
Daily Connections	5 Ø
Found on	7/1/2026

Valley Transit from San Antonio, TX to Indianapolis

Here you will find the key facts about the Valley Transit bus route San Antonio, TX to Indianapolis:

Cheapest Price	$133
Fastest Bus	31h 55m
Earliest Bus	9:00 PM
Last Bus	9:00 PM
Daily Connections	2 Ø
Found on	6/29/2026

All bus stations and stops in San Antonio, TX and Indianapolis

In the map below, you can see where to find all bus stations in San Antonio, TX and Indianapolis.

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

W. Southcross & Buffalo Bus Stop

Urban Loop

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from San Antonio, TX to Indianapolis

Want to know which seat classes are available on the buses from San Antonio, TX to Indianapolis? Or which bus companies serve the route San Antonio, TX to Indianapolis? Below you will find answers to your questions.

FAQs about the San Antonio, TX to Indianapolis bus

How much does a San Antonio, TX Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $116 and takes 33h 10m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to Indianapolis?

This route is offered by 4 companies with a range of ticket prices between $116 and $167. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from San Antonio, TX to Indianapolis each day?

Every day, the San Antonio, TX to Indianapolis bus route is served by approximately 11 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to Indianapolis take?

The fastest bus from San Antonio, TX to Indianapolis is offered by Greyhound Lines Mexico and takes 27h 25m. Bus tickets for this connection cost $125. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to Indianapolis?

The earliest bus arriving in Indianapolis from San Antonio, TX starts at 1:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to Indianapolis?

The latest bus trip departing from San Antonio, TX for Indianapolis starts at 9:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX Indianapolis route?

When traveling by bus from San Antonio, TX to Indianapolis, passengers can travel with FlixBus, Greyhound US and Greyhound Lines Mexico. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and Indianapolis?

You can check all the direct connections between San Antonio, TX and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound US and Greyhound Lines Mexico.

What can I take with me on the San Antonio, TX to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from San Antonio, TX to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 11 daily trips between San Antonio, TX and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Antonio, TX to Indianapolis?

Prices and availability for 11 trips between San Antonio, TX and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Antonio, TX to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to Indianapolis

Here’s an overview of the most popular bus routes to San Antonio, TX and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!