Which bus from Mesa, AZ to San Diego is the cheapest?

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Compare all timetables for the bus from Mesa, AZ to San Diego

Here is a selection of the cheapest bus trips from the schedule from Mesa, AZ to San Diego from various bus operators like Greyhound US for the next days.

today
$56
tomorrow
$59
Wednesday
$60
Thursday
$63
Friday
$74
Saturday
$74
Sunday
$71

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 50m 7:55 PM Mesa, AZ Greyhound 11:45 AM San Diego Old Town Transit Center  Economy $56
Greyhound US 20h 30m 7:55 PM Mesa, AZ Greyhound 4:25 PM San Diego Old Town Transit Center  Economy $57
  • Did you know that if you travel from Mesa, AZ to San Diego via Phoenix, AZ, you can save more than $9? You can find the corresponding connections below.
    • Greyhound US
      21h 50m
      0
      7:55 PM
      Mesa, AZ
      Greyhound
      8:15 PM
      Phoenix, AZ
      Bus Station
      0
      Greyhound US
      Economy
      $3
      • Waiting Time 13h 40m
    • Greyhound US
      7h 50m
      0
      9:55 AM
      Phoenix, AZ
      Bus Station
      5:45 PM
      San Diego
      Old Town Transit Center
      0
      Greyhound US
      Economy
      $44
    Travel time is 6h 0m longer, but you will save $9

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 30m 7:55 PM Mesa, AZ Greyhound 4:25 PM San Diego Old Town Transit Center  Economy $59
Greyhound US 15h 50m 7:55 PM Mesa, AZ Greyhound 11:45 AM San Diego Old Town Transit Center  Economy $60
Greyhound US 20h 0m 7:55 PM Mesa, AZ Greyhound 3:55 PM San Diego La Jolla Village  Economy $60
  • Did you know that if you travel from Mesa, AZ to San Diego via Phoenix, AZ, you can save more than $12? You can find the corresponding connections below.
    • Greyhound US
      21h 50m
      0
      7:55 PM
      Mesa, AZ
      Greyhound
      8:15 PM
      Phoenix, AZ
      Bus Station
      0
      Greyhound US
      Economy
      $3
      • Waiting Time 13h 40m
    • Greyhound US
      7h 50m
      0
      9:55 AM
      Phoenix, AZ
      Bus Station
      5:45 PM
      San Diego
      Old Town Transit Center
      0
      Greyhound US
      Economy
      $44
    Travel time is 6h 0m longer, but you will save $12

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 50m 7:55 PM Mesa, AZ Greyhound 11:45 AM San Diego Old Town Transit Center  Economy $60
Greyhound US 20h 30m 7:55 PM Mesa, AZ Greyhound 4:25 PM San Diego Old Town Transit Center  Economy $61
Greyhound US 16h 25m 7:55 PM Mesa, AZ Greyhound 12:20 PM San Diego San Ysidro Transit Center  Economy $66
Greyhound US 22h 25m 7:55 PM Mesa, AZ Greyhound 6:20 PM San Diego San Ysidro Transit Center  Economy $66
  • Did you know that if you travel from Mesa, AZ to San Diego via Phoenix, AZ, you can save more than $13? You can find the corresponding connections below.
    • Greyhound US
      21h 50m
      0
      7:55 PM
      Mesa, AZ
      Greyhound
      8:15 PM
      Phoenix, AZ
      Bus Station
      0
      Greyhound US
      Economy
      $3
      • Waiting Time 13h 40m
    • Greyhound US
      7h 50m
      0
      9:55 AM
      Phoenix, AZ
      Bus Station
      5:45 PM
      San Diego
      Old Town Transit Center
      0
      Greyhound US
      Economy
      $44
    Travel time is 6h 0m longer, but you will save $13

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 50m 7:55 PM Mesa, AZ Greyhound 11:45 AM San Diego Old Town Transit Center  Economy $63
Greyhound US 20h 30m 7:55 PM Mesa, AZ Greyhound 4:25 PM San Diego Old Town Transit Center  Economy $65
Greyhound US 16h 25m 7:55 PM Mesa, AZ Greyhound 12:20 PM San Diego San Ysidro Transit Center  Economy $66
Greyhound US 22h 25m 7:55 PM Mesa, AZ Greyhound 6:20 PM San Diego San Ysidro Transit Center  Economy $66
Greyhound US 20h 0m 7:55 PM Mesa, AZ Greyhound 3:55 PM San Diego La Jolla Village  Economy $68
  • Did you know that if you travel from Mesa, AZ to San Diego via Phoenix, AZ, you can save more than $16? You can find the corresponding connections below.
    • Greyhound US
      21h 50m
      0
      7:55 PM
      Mesa, AZ
      Greyhound
      8:15 PM
      Phoenix, AZ
      Bus Station
      0
      Greyhound US
      Economy
      $3
      • Waiting Time 13h 40m
    • Greyhound US
      7h 50m
      0
      9:55 AM
      Phoenix, AZ
      Bus Station
      5:45 PM
      San Diego
      Old Town Transit Center
      0
      Greyhound US
      Economy
      $44
    Travel time is 6h 0m longer, but you will save $16

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 16h 25m 7:55 PM Mesa, AZ Greyhound 12:20 PM San Diego San Ysidro Transit Center  Economy $74
Greyhound US 22h 25m 7:55 PM Mesa, AZ Greyhound 6:20 PM San Diego San Ysidro Transit Center  Economy $74
Greyhound US 14h 10m 7:55 PM Mesa, AZ Greyhound 10:05 AM San Diego Seaport Village  Economy $75
Greyhound US 20h 30m 7:55 PM Mesa, AZ Greyhound 4:25 PM San Diego Old Town Transit Center  Economy $75
Greyhound US 15h 50m 7:55 PM Mesa, AZ Greyhound 11:45 AM San Diego Old Town Transit Center  Economy $75
  • Did you know that if you travel from Mesa, AZ to San Diego via Phoenix, AZ, you can save more than $16? You can find the corresponding connections below.
    • Greyhound US
      15h 50m
      0
      7:55 PM
      Mesa, AZ
      Greyhound
      8:15 PM
      Phoenix, AZ
      Bus Station
      0
      Greyhound US
      Economy
      $3
      • Waiting Time 1h 20m
    • Greyhound US
      14h 10m
      0
      9:35 PM
      Phoenix, AZ
      Bus Station
      11:45 AM
      San Diego
      Old Town Transit Center
      0
      Greyhound US
      Economy
      $55
    Travel time is 1h 40m longer, but you will save $16

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 14h 10m 7:55 PM Mesa, AZ Greyhound 10:05 AM San Diego Seaport Village  Economy $74
Greyhound US 15h 50m 7:55 PM Mesa, AZ Greyhound 11:45 AM San Diego Old Town Transit Center  Economy $74
Greyhound US 20h 30m 7:55 PM Mesa, AZ Greyhound 4:25 PM San Diego Old Town Transit Center  Economy $75
  • Did you know that if you travel from Mesa, AZ to San Diego via Phoenix, AZ, you can save more than $16? You can find the corresponding connections below.
    • Greyhound US
      15h 50m
      0
      7:55 PM
      Mesa, AZ
      Greyhound
      8:15 PM
      Phoenix, AZ
      Bus Station
      0
      Greyhound US
      Economy
      $3
      • Waiting Time 1h 20m
    • Greyhound US
      14h 10m
      0
      9:35 PM
      Phoenix, AZ
      Bus Station
      11:45 AM
      San Diego
      Old Town Transit Center
      0
      Greyhound US
      Economy
      $55
    Travel time is 1h 40m longer, but you will save $16

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 16h 25m 7:55 PM Mesa, AZ Greyhound 12:20 PM San Diego San Ysidro Transit Center  Economy $71
Greyhound US 22h 25m 7:55 PM Mesa, AZ Greyhound 6:20 PM San Diego San Ysidro Transit Center  Economy $71
Greyhound US 20h 30m 7:55 PM Mesa, AZ Greyhound 4:25 PM San Diego Old Town Transit Center  Economy $73
Greyhound US 15h 50m 7:55 PM Mesa, AZ Greyhound 11:45 AM San Diego Old Town Transit Center  Economy $73
Greyhound US 20h 0m 7:55 PM Mesa, AZ Greyhound 3:55 PM San Diego La Jolla Village  Economy $76
  • Did you know that if you travel from Mesa, AZ to San Diego via Phoenix, AZ, you can save more than $24? You can find the corresponding connections below.
    • Greyhound US
      21h 50m
      0
      7:55 PM
      Mesa, AZ
      Greyhound
      8:15 PM
      Phoenix, AZ
      Bus Station
      0
      Greyhound US
      Economy
      $3
      • Waiting Time 13h 40m
    • Greyhound US
      7h 50m
      0
      9:55 AM
      Phoenix, AZ
      Bus Station
      5:45 PM
      San Diego
      Old Town Transit Center
      0
      Greyhound US
      Economy
      $44
    Travel time is 6h 0m longer, but you will save $24

Best Price Offer: The price for the cheapest bus from Mesa, AZ to San Diego is $52 on 8/12/2026. Flexible travelers save on ticket prices.


Facts about the bus from Mesa, AZ to San Diego

Compare all providers like Greyhound US that travel 4 times every day by bus from Mesa, AZ to San Diego in one click! Book your bus ticket from Mesa, AZ to San Diego starting from $52!

Cheapest Bus $52
Fastest Bus 14h 10m
Earliest Bus 7:55 PM
Latest Bus 7:55 PM
Daily Bus Routes 4 Ø
Distance 311.8 miles
Bus Companies Greyhound US

Cheapest bus connections from Mesa, AZ to San Diego

Every day, 4 buses from 1 bus companies leave Mesa, AZ for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/27/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 07/26
Monday 07/27
$56
Tuesday 07/28
$59
Wednesday 07/29
$66
Thursday 07/30
$67
Friday 07/31
$74
Saturday 08/01
$74
Sunday 08/02
$71
Monday 08/03
$61
Tuesday 08/04
$62
Wednesday 08/05
$74
Thursday 08/06
$77
Friday 08/07
$66
Saturday 08/08
$60
Sunday 08/09
$60
Monday 08/10
$55
Tuesday 08/11
$60
Wednesday 08/12
$52
Thursday 08/13
Friday 08/14
$65
Saturday 08/15
$57
Sunday 08/16
$57
Monday 08/17
$53
Tuesday 08/18
Wednesday 08/19
$60
Thursday 08/20
$59
Friday 08/21
$61
Saturday 08/22

How to save money travelling from Mesa, AZ to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Mesa, AZ to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Mesa, AZ to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Mesa, AZ to San Diego are also emptier.

All bus stations and stops in Mesa, AZ and San Diego

In the map below, you can see where to find all bus stations in Mesa, AZ and San Diego.

Service and Comfort on the bus from Mesa, AZ to San Diego

Want to know which seat classes are available on the buses from Mesa, AZ to San Diego? Or which bus companies serve the route Mesa, AZ to San Diego? Below you will find answers to your questions.

FAQs about the Mesa, AZ to San Diego bus

How much does a Mesa, AZ San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $52 and takes 15h 50m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Mesa, AZ to San Diego?

This route is offered by 1 companies with a range of ticket prices between $52 and $77. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Mesa, AZ to San Diego each day?

Every day, the Mesa, AZ to San Diego bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Mesa, AZ to San Diego take?

The fastest bus from Mesa, AZ to San Diego is offered by Greyhound US and takes 14h 10m. Bus tickets for this connection cost $75. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Mesa, AZ to San Diego?

The earliest bus arriving in San Diego from Mesa, AZ starts at 7:55 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Mesa, AZ to San Diego?

The latest bus trip departing from Mesa, AZ for San Diego starts at 7:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Mesa, AZ San Diego route?

When traveling by bus from Mesa, AZ to San Diego, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Mesa, AZ and San Diego?

You can check all the direct connections between Mesa, AZ and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Mesa, AZ to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Mesa, AZ San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Mesa, AZ San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mesa, AZ to San Diego on your planned travel date.

How does CheckMyBus find the best bus deals from Mesa, AZ to San Diego?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Mesa, AZ and San Diego. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Mesa, AZ to San Diego?

Prices and availability for 4 trips between Mesa, AZ and San Diego change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Mesa, AZ to San Diego

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Mesa, AZ and to San Diego

Here’s an overview of the most popular bus routes to Mesa, AZ and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Bus Irvine, CA - San Diego Bus Irvine, CA - San Diego
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From Norwalk, CA to San Diego bus From Norwalk, CA to San Diego bus
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Popular Airport Shuttles to Mesa, AZ and to San Diego
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