Bus Lyon to Frankfurt am Main: Compare prices and save money

Compare all timetables for the bus from Lyon to Frankfurt am Main

Here is a selection of the cheapest bus trips from the schedule from Lyon to Frankfurt am Main from various bus operators like FlixBus or BlaBlaCar Bus for the next days.

today

$46

tomorrow

$48

Friday

$62

Saturday

$54

Sunday

$44

Monday

$41

Tuesday

$38

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	14h 30m	10:15 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	12:45 PM	Frankfurt am Main	Central Station	Economy	$46	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/9/2026 10:15:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/10/2026 12:45:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 14h 30m
FlixBus	12h 45m	5:05 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	5:50 AM	Frankfurt am Main	Central Station	Economy	$48	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/9/2026 5:05:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/10/2026 5:50:00 AM. 50 Economy ticket for $48 per person are available. Travel duration is 12h 45m
FlixBus	15h 5m	5:40 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:45 AM	Frankfurt am Main	Central Station	Economy	$48	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/9/2026 5:40:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/10/2026 8:45:00 AM. 50 Economy ticket for $48 per person are available. Travel duration is 15h 5m
FlixBus	12h 45m	7:30 AM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:15 PM	Frankfurt am Main	Central Station	Economy	$58	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/9/2026 7:30:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/9/2026 8:15:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 12h 45m
FlixBus	10h 30m	2:20 AM	Lyon	Lyon Avenue Tony Garnier Bus Stop	12:50 PM	Frankfurt am Main	Central Station	Economy	$66	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/9/2026 2:20:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/9/2026 12:50:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 10h 30m

Did you know that if you travel from Lyon to Frankfurt am Main via Strasbourg, you can save more than $6? You can find the corresponding connections below.
- BlaBlaCar Bus
  
  12h 10m
  
  0
  
  2:05 AM
  
  Lyon
  Perrache Train Station
  
  8:55 AM
  
  Strasbourg
  Place de l'Etoile
  
  0
  
  Economy
  
  $24
  
  A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/10/2026 2:05:00 AM to Place de l'Etoile, Strasbourg (France) arriving at 9/10/2026 8:55:00 AM. 50 Economy ticket for $24 per person are available. Travel duration is 6h 50m
- FlixBus
  
  4h 15m
  
  0
  
  10:00 AM
  
  Strasbourg
  Place de l'Etoile
  
  2:15 PM
  
  Frankfurt am Main
  Central Station
  
  0
  
  Economy
  
  $16
  
  A Bus from FlixBus goes from Place de l'Etoile, Strasbourg (France) at 9/10/2026 10:00:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/10/2026 2:15:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 4h 15m
Travel time is 1h 40m longer, but you will save $6

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	11h 15m	2:05 AM	Lyon	Perrache Train Station	1:20 PM	Frankfurt am Main	Central Bus Station	Economy	$48	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/10/2026 2:05:00 AM to Central Bus Station, Frankfurt am Main (Germany) arriving at 9/10/2026 1:20:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 11h 15m
FlixBus	12h 45m	7:30 AM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:15 PM	Frankfurt am Main	Central Station	Economy	$49	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/10/2026 7:30:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/10/2026 8:15:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 12h 45m
FlixBus	14h 40m	6:05 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:45 AM	Frankfurt am Main	Central Station	Economy	$51	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/10/2026 6:05:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/11/2026 8:45:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 14h 40m
FlixBus	12h 45m	5:05 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	5:50 AM	Frankfurt am Main	Central Station	Economy	$59	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/10/2026 5:05:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/11/2026 5:50:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 12h 45m

Did you know that if you travel from Lyon to Frankfurt am Main via Strasbourg, you can save more than $8? You can find the corresponding connections below.
- BlaBlaCar Bus
  
  12h 10m
  
  0
  
  2:05 AM
  
  Lyon
  Perrache Train Station
  
  8:55 AM
  
  Strasbourg
  Place de l'Etoile
  
  0
  
  Economy
  
  $24
  
  A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/10/2026 2:05:00 AM to Place de l'Etoile, Strasbourg (France) arriving at 9/10/2026 8:55:00 AM. 50 Economy ticket for $24 per person are available. Travel duration is 6h 50m
- FlixBus
  
  4h 15m
  
  0
  
  10:00 AM
  
  Strasbourg
  Place de l'Etoile
  
  2:15 PM
  
  Frankfurt am Main
  Central Station
  
  0
  
  Economy
  
  $16
  
  A Bus from FlixBus goes from Place de l'Etoile, Strasbourg (France) at 9/10/2026 10:00:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/10/2026 2:15:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 4h 15m
Travel time is 0h 55m longer, but you will save $8

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	13h 55m	6:05 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:00 AM	Frankfurt am Main	Central Station	Economy	$62	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/11/2026 6:05:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/12/2026 8:00:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 13h 55m
FlixBus	12h 45m	7:30 AM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:15 PM	Frankfurt am Main	Central Station	Economy	$64	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/11/2026 7:30:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/11/2026 8:15:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 12h 45m
FlixBus	11h 45m	11:00 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	10:45 AM	Frankfurt am Main	Central Station	Economy	$66	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/11/2026 11:00:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/12/2026 10:45:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 11h 45m
FlixBus	12h 45m	5:05 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	5:50 AM	Frankfurt am Main	Central Station	Economy	$67	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/11/2026 5:05:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/12/2026 5:50:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 12h 45m
FlixBus	10h 30m	2:20 AM	Lyon	Lyon Avenue Tony Garnier Bus Stop	12:50 PM	Frankfurt am Main	Central Station	Economy	$72	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/11/2026 2:20:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/11/2026 12:50:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 10h 30m

Did you know that if you travel from Lyon to Frankfurt am Main via Strasbourg, you can save more than $22? You can find the corresponding connections below.
- BlaBlaCar Bus
  
  12h 10m
  
  0
  
  2:05 AM
  
  Lyon
  Perrache Train Station
  
  8:55 AM
  
  Strasbourg
  Place de l'Etoile
  
  0
  
  Economy
  
  $24
  
  A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/10/2026 2:05:00 AM to Place de l'Etoile, Strasbourg (France) arriving at 9/10/2026 8:55:00 AM. 50 Economy ticket for $24 per person are available. Travel duration is 6h 50m
- FlixBus
  
  4h 15m
  
  0
  
  10:00 AM
  
  Strasbourg
  Place de l'Etoile
  
  2:15 PM
  
  Frankfurt am Main
  Central Station
  
  0
  
  Economy
  
  $16
  
  A Bus from FlixBus goes from Place de l'Etoile, Strasbourg (France) at 9/10/2026 10:00:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/10/2026 2:15:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 4h 15m
Travel time is 1h 40m longer, but you will save $22

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	12h 45m	7:30 AM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:15 PM	Frankfurt am Main	Central Station	Economy	$54	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/12/2026 7:30:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/12/2026 8:15:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 12h 45m
BlaBlaCar Bus	10h 50m	3:20 AM	Lyon	Perrache Train Station	2:10 PM	Frankfurt am Main	Central Bus Station	Economy	$58	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/12/2026 3:20:00 AM to Central Bus Station, Frankfurt am Main (Germany) arriving at 9/12/2026 2:10:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 10h 50m
FlixBus	11h 45m	11:00 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	10:45 AM	Frankfurt am Main	Central Station	Economy	$60	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/12/2026 11:00:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/13/2026 10:45:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 11h 45m
BlaBlaCar Bus	11h 15m	2:05 AM	Lyon	Perrache Train Station	1:20 PM	Frankfurt am Main	Central Bus Station	Economy	$64	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/12/2026 2:05:00 AM to Central Bus Station, Frankfurt am Main (Germany) arriving at 9/12/2026 1:20:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 11h 15m
FlixBus	10h 30m	2:20 AM	Lyon	Lyon Avenue Tony Garnier Bus Stop	12:50 PM	Frankfurt am Main	Central Station	Economy	$66	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/12/2026 2:20:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/12/2026 12:50:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 10h 30m

Did you know that if you travel from Lyon to Frankfurt am Main via Strasbourg, you can save more than $14? You can find the corresponding connections below.
- BlaBlaCar Bus
  
  12h 10m
  
  0
  
  2:05 AM
  
  Lyon
  Perrache Train Station
  
  8:55 AM
  
  Strasbourg
  Place de l'Etoile
  
  0
  
  Economy
  
  $24
  
  A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/10/2026 2:05:00 AM to Place de l'Etoile, Strasbourg (France) arriving at 9/10/2026 8:55:00 AM. 50 Economy ticket for $24 per person are available. Travel duration is 6h 50m
- FlixBus
  
  4h 15m
  
  0
  
  10:00 AM
  
  Strasbourg
  Place de l'Etoile
  
  2:15 PM
  
  Frankfurt am Main
  Central Station
  
  0
  
  Economy
  
  $16
  
  A Bus from FlixBus goes from Place de l'Etoile, Strasbourg (France) at 9/10/2026 10:00:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/10/2026 2:15:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 4h 15m
Travel time is 1h 40m longer, but you will save $14

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 50m	3:20 AM	Lyon	Perrache Train Station	2:10 PM	Frankfurt am Main	Central Bus Station	Economy	$44	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/13/2026 3:20:00 AM to Central Bus Station, Frankfurt am Main (Germany) arriving at 9/13/2026 2:10:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 10h 50m
FlixBus	11h 45m	11:00 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	10:45 AM	Frankfurt am Main	Central Station	Economy	$56	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/13/2026 11:00:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/14/2026 10:45:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 11h 45m
FlixBus	12h 45m	7:30 AM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:15 PM	Frankfurt am Main	Central Station	Economy	$64	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/13/2026 7:30:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/13/2026 8:15:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 12h 45m
FlixBus	10h 30m	2:20 AM	Lyon	Lyon Avenue Tony Garnier Bus Stop	12:50 PM	Frankfurt am Main	Central Station	Economy	$72	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/13/2026 2:20:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/13/2026 12:50:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 10h 30m

Did you know that if you travel from Lyon to Frankfurt am Main via Strasbourg, you can save more than $4? You can find the corresponding connections below.
- BlaBlaCar Bus
  
  11h 15m
  
  0
  
  2:05 AM
  
  Lyon
  Perrache Train Station
  
  8:55 AM
  
  Strasbourg
  Place de l'Etoile
  
  0
  
  Economy
  
  $27
  
  A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/14/2026 2:05:00 AM to Place de l'Etoile, Strasbourg (France) arriving at 9/14/2026 8:55:00 AM. 50 Economy ticket for $27 per person are available. Travel duration is 6h 50m
- BlaBlaCar Bus
  
  4h 20m
  
  0
  
  9:00 AM
  
  Strasbourg
  Place de l'Etoile
  
  1:20 PM
  
  Frankfurt am Main
  Central Bus Station
  
  0
  
  Economy
  
  $13
  
  A Bus from BlaBlaCar Bus goes from Place de l'Etoile, Strasbourg (France) at 9/14/2026 9:00:00 AM to Central Bus Station, Frankfurt am Main (Germany) arriving at 9/14/2026 1:20:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 4h 20m
Travel time is 0h 45m longer, but you will save $4

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	14h 40m	6:05 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:45 AM	Frankfurt am Main	Central Station	Economy	$41	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/14/2026 6:05:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/15/2026 8:45:00 AM. 50 Economy ticket for $41 per person are available. Travel duration is 14h 40m
FlixBus	12h 45m	7:30 AM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:15 PM	Frankfurt am Main	Central Station	Economy	$43	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/14/2026 7:30:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/14/2026 8:15:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 12h 45m
BlaBlaCar Bus	11h 15m	2:05 AM	Lyon	Perrache Train Station	1:20 PM	Frankfurt am Main	Central Bus Station	Economy	$44	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/14/2026 2:05:00 AM to Central Bus Station, Frankfurt am Main (Germany) arriving at 9/14/2026 1:20:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 11h 15m
FlixBus	11h 45m	11:00 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	10:45 AM	Frankfurt am Main	Central Station	Economy	$49	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/14/2026 11:00:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/15/2026 10:45:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 11h 45m

Did you know that if you travel from Lyon to Frankfurt am Main via Colmar, you can save more than $8? You can find the corresponding connections below.
- BlaBlaCar Bus
  
  10h 50m
  
  0
  
  3:20 AM
  
  Lyon
  Perrache Train Station
  
  9:05 AM
  
  Colmar
  Bus Stop
  
  0
  
  Economy
  
  $26
  
  A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/15/2026 3:20:00 AM to Bus Stop, Colmar (France) arriving at 9/15/2026 9:05:00 AM. 50 Economy ticket for $26 per person are available. Travel duration is 5h 45m
- BlaBlaCar Bus
  
  5h 0m
  
  0
  
  9:10 AM
  
  Colmar
  Bus Stop
  
  2:10 PM
  
  Frankfurt am Main
  Central Bus Station
  
  0
  
  Economy
  
  $7
  
  A Bus from BlaBlaCar Bus goes from Bus Stop, Colmar (France) at 9/15/2026 9:10:00 AM to Central Bus Station, Frankfurt am Main (Germany) arriving at 9/15/2026 2:10:00 PM. 50 Economy ticket for $7 per person are available. Travel duration is 5h 0m
Travel Time is 0h 25m shorter, and you will save $8

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 50m	3:20 AM	Lyon	Perrache Train Station	2:10 PM	Frankfurt am Main	Central Bus Station	Economy	$38	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/15/2026 3:20:00 AM to Central Bus Station, Frankfurt am Main (Germany) arriving at 9/15/2026 2:10:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 10h 50m
FlixBus	12h 45m	5:05 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	5:50 AM	Frankfurt am Main	Central Station	Economy	$40	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/15/2026 5:05:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/16/2026 5:50:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 12h 45m
FlixBus	14h 40m	6:05 PM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:45 AM	Frankfurt am Main	Central Station	Economy	$40	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/15/2026 6:05:00 PM to Central Station, Frankfurt am Main (Germany) arriving at 9/16/2026 8:45:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 14h 40m
FlixBus	12h 45m	7:30 AM	Lyon	Lyon Avenue Tony Garnier Bus Stop	8:15 PM	Frankfurt am Main	Central Station	Economy	$42	A Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 9/15/2026 7:30:00 AM to Central Station, Frankfurt am Main (Germany) arriving at 9/15/2026 8:15:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 12h 45m

Did you know that if you travel from Lyon to Frankfurt am Main via Colmar, you can save more than $5? You can find the corresponding connections below.
- BlaBlaCar Bus
  
  10h 50m
  
  0
  
  3:20 AM
  
  Lyon
  Perrache Train Station
  
  9:05 AM
  
  Colmar
  Bus Stop
  
  0
  
  Economy
  
  $26
  
  A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 9/15/2026 3:20:00 AM to Bus Stop, Colmar (France) arriving at 9/15/2026 9:05:00 AM. 50 Economy ticket for $26 per person are available. Travel duration is 5h 45m
- BlaBlaCar Bus
  
  5h 0m
  
  0
  
  9:10 AM
  
  Colmar
  Bus Stop
  
  2:10 PM
  
  Frankfurt am Main
  Central Bus Station
  
  0
  
  Economy
  
  $7
  
  A Bus from BlaBlaCar Bus goes from Bus Stop, Colmar (France) at 9/15/2026 9:10:00 AM to Central Bus Station, Frankfurt am Main (Germany) arriving at 9/15/2026 2:10:00 PM. 50 Economy ticket for $7 per person are available. Travel duration is 5h 0m
Travel time is the same as the direct connection, but you will save $5

Best Price Offer: The price for the cheapest bus from Lyon to Frankfurt am Main is $36 on 9/22/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Lyon and Frankfurt am Main

See here how frequent the connections between Lyon and Frankfurt am Main are, during different times and days of the week.

Monday is the busiest day, with more than 6 daily buses from Lyon to Frankfurt am Main. Sunday has instead the fewest connections, with only 5 daily coaches between Lyon and Frankfurt am Main.

The busiest time of the day is the Evening, with 13 buses from Lyon to Frankfurt am Main, while Afternoon sees the fewest connections between Lyon and Frankfurt am Main, with 6 offers.

Facts about the bus from Lyon to Frankfurt am Main

Compare all providers like FlixBus and BlaBlaCar Bus that travel 5 times every day by bus from Lyon to Frankfurt am Main in one click! Book your bus ticket from Lyon to Frankfurt am Main starting from $36!

Cheapest Bus	$36
Fastest Bus	10h 30m
Earliest Bus	2:20 AM
Latest Bus	11:00 PM
Daily Bus Routes	5 Ø
Distance	349.5 miles
Bus Companies	FlixBus and BlaBlaCar Bus

Cheapest bus connections from Lyon to Frankfurt am Main

Every day, 5 buses from 2 bus companies leave Lyon for Frankfurt am Main: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/09/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/06

Monday 09/07

Tuesday 09/08

Wednesday 09/09

$46

Thursday 09/10

$49

Friday 09/11

$62

Saturday 09/12

$54

Sunday 09/13

$56

Monday 09/14

$41

Tuesday 09/15

$40

Wednesday 09/16

$40

Thursday 09/17

$41

Friday 09/18

$45

Saturday 09/19

$44

Sunday 09/20

$49

Monday 09/21

$37

Tuesday 09/22

$36

Wednesday 09/23

$37

Thursday 09/24

$40

Friday 09/25

$47

Saturday 09/26

$41

Sunday 09/27

$43

Monday 09/28

$45

Tuesday 09/29

$45

Wednesday 09/30

$45

Thursday 10/01

$45

Friday 10/02

$45

Saturday 10/03

The cheapest time to travel from Lyon to Frankfurt am Main

See here on which day and which time of the day you can find the cheapest bus ticket from Lyon to Frankfurt am Main, for the next 30 days.

With a price starting from $36, Tuesday is the cheapest day for a bus from Lyon to Frankfurt am Main. Friday instead is the most expensive day with prices starting from $45.

Night is the cheapest day time for bus tickets from Lyon to Frankfurt am Main, with $36. Morning is the most expensive time of the day with prices starting from $42.

How to save money travelling from Lyon to Frankfurt am Main

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Lyon to Frankfurt am Main in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Lyon to Frankfurt am Main, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Lyon to Frankfurt am Main are also emptier.

Beloved bus companies from Lyon to Frankfurt am Main

These are the most booked bus companies between Lyon to Frankfurt am Main from our users.

FlixBus from Lyon to Frankfurt am Main

Here you will find the key facts about the FlixBus bus route Lyon to Frankfurt am Main:

Cheapest Price	$40
Fastest Bus	10h 30m
Earliest Bus	2:20 AM
Last Bus	11:00 PM
Daily Connections	4 Ø
Found on	9/9/2026

BlaBlaCar Bus from Lyon to Frankfurt am Main

Here you will find the key facts about the BlaBlaCar Bus bus route Lyon to Frankfurt am Main:

Cheapest Price	$38
Fastest Bus	10h 50m
Earliest Bus	2:05 AM
Last Bus	3:20 AM
Daily Connections	1 Ø
Found on	9/7/2026

All bus stations and stops in Lyon and Frankfurt am Main

In the map below, you can see where to find all bus stations in Lyon and Frankfurt am Main.

Perrache Bus Stop

Cours de Verdun 14

Lyon Avenue Tony Garnier Bus Stop

Avenue Tony Garnier 52

Pont Kitchener R.G. Bus Stop

Cours de Verdun

Maison Carrée Bus Stop

Les Charrières 69570

Girondins - Yves Farge Bus Stop

Central Bus Station

Karlsruher Straße 10

Stuttgarter Strasse Bus Stop

Stuttgarter Str.

Seilerstraße Bus Stop

Stresemannallee/Mörfelder Landstr. Bus Stop

Baseler Platz Bus Stop

Service and Comfort on the bus from Lyon to Frankfurt am Main

Want to know which seat classes are available on the buses from Lyon to Frankfurt am Main? Or which bus companies serve the route Lyon to Frankfurt am Main? Below you will find answers to your questions.

FAQs about the Lyon to Frankfurt am Main bus

How much does a Lyon Frankfurt am Main bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $36 and takes 10h 50m to reach Frankfurt am Main. Compare offers to save money!

How much could I save by comparing buses from Lyon to Frankfurt am Main?

This route is offered by 2 companies with a range of ticket prices between $36 and $79. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Frankfurt am Main.

On average, how many connections are available from Lyon to Frankfurt am Main each day?

Every day, the Lyon to Frankfurt am Main bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Lyon to Frankfurt am Main take?

The fastest bus from Lyon to Frankfurt am Main is offered by FlixBus and takes 10h 30m. Bus tickets for this connection cost $66. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Lyon to Frankfurt am Main?

The earliest bus arriving in Frankfurt am Main from Lyon starts at 2:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Lyon to Frankfurt am Main?

The latest bus trip departing from Lyon for Frankfurt am Main starts at 11:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Lyon Frankfurt am Main route?

When traveling by bus from Lyon to Frankfurt am Main, passengers can travel with FlixBus and BlaBlaCar Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Lyon and Frankfurt am Main?

You can check all the direct connections between Lyon and Frankfurt am Main by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and BlaBlaCar Bus.

What can I take with me on the Lyon to Frankfurt am Main bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Lyon Frankfurt am Main bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Lyon Frankfurt am Main bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Lyon to Frankfurt am Main on your planned travel date.

How does CheckMyBus find the best bus deals from Lyon to Frankfurt am Main?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Lyon and Frankfurt am Main. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Lyon to Frankfurt am Main?

Prices and availability for 5 trips between Lyon and Frankfurt am Main change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Lyon to Frankfurt am Main

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Lyon and to Frankfurt am Main

Here’s an overview of the most popular bus routes to Lyon and to Frankfurt am Main. Simply click on the connection of your choice, and you will find all the details about your bus route!