Bus Indianapolis to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Indianapolis to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Indianapolis to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.

today

$90

tomorrow

$86

Tuesday

$86

Wednesday

$89

Thursday

$77

Friday

Saturday

$83

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 5m	6:35 PM	Indianapolis	Washington / Delaware	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$90	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/26/2026 6:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/27/2026 10:40:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 16h 5m
Greyhound US	15h 0m	7:40 PM	Indianapolis	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$92	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/26/2026 7:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/27/2026 10:40:00 AM. 50 Economy ticket for $92 per person are available. Travel duration is 15h 0m
Greyhound US	15h 50m	8:10 PM	Indianapolis	Central Bus Station	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$92	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/26/2026 8:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/27/2026 12:00:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 15h 50m
FlixBus	16h 45m	11:25 PM	Indianapolis	Washington / Delaware	4:10 PM	Greenville, SC	Woodruff Rd	Economy	$92	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/26/2026 11:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/27/2026 4:10:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 16h 45m
Greyhound US	14h 55m	4:05 PM	Indianapolis	Central Bus Station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$96	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/26/2026 4:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/27/2026 7:00:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 14h 55m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 55m	4:05 PM	Indianapolis	Central Bus Station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/27/2026 4:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/28/2026 7:00:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 14h 55m
Greyhound US	15h 0m	7:40 PM	Indianapolis	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/27/2026 7:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/28/2026 10:40:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 15h 0m
Greyhound US	20h 0m	8:10 PM	Indianapolis	Central Bus Station	4:10 PM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/27/2026 8:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/28/2026 4:10:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 20h 0m
FlixBus	16h 5m	6:35 PM	Indianapolis	Downtown Transit Center	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 7/27/2026 6:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/28/2026 10:40:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 16h 5m
FlixBus	16h 45m	11:25 PM	Indianapolis	Downtown Transit Center	4:10 PM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 7/27/2026 11:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/28/2026 4:10:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 16h 45m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 50m	4:40 AM	Indianapolis	Central Bus Station	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/28/2026 4:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/28/2026 9:30:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 16h 50m
Greyhound US	14h 55m	4:05 PM	Indianapolis	Central Bus Station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/28/2026 4:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/29/2026 7:00:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 14h 55m
Greyhound US	15h 0m	7:40 PM	Indianapolis	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/28/2026 7:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/29/2026 10:40:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 15h 0m
FlixBus	16h 5m	6:35 PM	Indianapolis	Downtown Transit Center	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 7/28/2026 6:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/29/2026 10:40:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 16h 5m
FlixBus	16h 45m	11:25 PM	Indianapolis	Downtown Transit Center	4:10 PM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 7/28/2026 11:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/29/2026 4:10:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 16h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 50m	4:40 AM	Indianapolis	Central Bus Station	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$89	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/29/2026 4:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/29/2026 9:30:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 16h 50m
Greyhound US	14h 55m	4:05 PM	Indianapolis	Central Bus Station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$89	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/29/2026 4:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2026 7:00:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 14h 55m
Greyhound US	15h 50m	8:10 PM	Indianapolis	Central Bus Station	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$89	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/29/2026 8:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2026 12:00:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 15h 50m
FlixBus	22h 15m	4:20 PM	Indianapolis	Washington / Delaware	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$89	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/29/2026 4:20:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2026 2:35:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 22h 15m
FlixBus	16h 45m	11:25 PM	Indianapolis	Washington / Delaware	4:10 PM	Greenville, SC	Woodruff Rd	Economy	$89	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/29/2026 11:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2026 4:10:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 16h 45m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 5m	6:35 PM	Indianapolis	Downtown Transit Center	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$77	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 7/30/2026 6:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/31/2026 10:40:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 16h 5m
Greyhound US	16h 50m	4:40 AM	Indianapolis	Central Bus Station	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$78	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/30/2026 4:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2026 9:30:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 16h 50m
Greyhound US	14h 55m	4:05 PM	Indianapolis	Central Bus Station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$78	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/30/2026 4:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/31/2026 7:00:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 14h 55m
Greyhound US	15h 0m	7:40 PM	Indianapolis	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$78	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/30/2026 7:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/31/2026 10:40:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 15h 0m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 50m	4:40 AM	Indianapolis	Central Bus Station	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$83	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 8/1/2026 4:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/1/2026 9:30:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 16h 50m
Greyhound US	14h 55m	4:05 PM	Indianapolis	Central Bus Station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$83	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 8/1/2026 4:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/2/2026 7:00:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 14h 55m
Greyhound US	15h 50m	8:10 PM	Indianapolis	Central Bus Station	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$83	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 8/1/2026 8:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/2/2026 12:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 15h 50m
FlixBus	16h 5m	6:35 PM	Indianapolis	Downtown Transit Center	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$83	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 8/1/2026 6:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/2/2026 10:40:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 16h 5m
FlixBus	16h 45m	11:25 PM	Indianapolis	Downtown Transit Center	4:10 PM	Greenville, SC	Woodruff Rd	Economy	$83	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 8/1/2026 11:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/2/2026 4:10:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 16h 45m

Best Price Offer: The price for the cheapest bus from Indianapolis to Greenville, SC is $77 on 7/30/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Indianapolis and Greenville, SC

See here how frequent the connections between Indianapolis and Greenville, SC are, during different times and days of the week.

Monday is the busiest day, with more than 16 daily buses from Indianapolis to Greenville, SC. Sunday has instead the fewest connections, with only 5 daily coaches between Indianapolis and Greenville, SC.

The busiest time of the day is the Evening, with 37 buses from Indianapolis to Greenville, SC, while Morning sees the fewest connections between Indianapolis and Greenville, SC, with 8 offers.

Facts about the bus from Indianapolis to Greenville, SC

Compare all providers like Greyhound US and FlixBus that travel 10 times every day by bus from Indianapolis to Greenville, SC in one click! Book your bus ticket from Indianapolis to Greenville, SC starting from $77!

Cheapest Bus	$77
Fastest Bus	14h 55m
Earliest Bus	4:05 PM
Latest Bus	11:25 PM
Daily Bus Routes	10 Ø
Distance	397.5 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Indianapolis to Greenville, SC

Every day, 10 buses from 2 bus companies leave Indianapolis for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

$99

Monday 07/27

$95

Tuesday 07/28

$90

Wednesday 07/29

$89

Thursday 07/30

$77

Friday 07/31

$98

Saturday 08/01

$87

Sunday 08/02

$86

Monday 08/03

$97

Tuesday 08/04

$85

Wednesday 08/05

$78

Thursday 08/06

$97

Friday 08/07

$97

Saturday 08/08

$81

Sunday 08/09

$85

Monday 08/10

$90

Tuesday 08/11

$97

Wednesday 08/12

$85

Thursday 08/13

$83

Friday 08/14

$85

Saturday 08/15

Sunday 08/16

$81

Monday 08/17

Tuesday 08/18

Wednesday 08/19

$80

Thursday 08/20

$100

Friday 08/21

Saturday 08/22

The cheapest time to travel from Indianapolis to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Indianapolis to Greenville, SC, for the next 30 days.

With a price starting from $77, Thursday is the cheapest day for a bus from Indianapolis to Greenville, SC. Monday instead is the most expensive day with prices starting from $86.

Evening is the cheapest day time for bus tickets from Indianapolis to Greenville, SC, with $77. Morning is the most expensive time of the day with prices starting from $81.

How to save money travelling from Indianapolis to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Indianapolis to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Indianapolis to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Indianapolis to Greenville, SC are also emptier.

All bus stations and stops in Indianapolis and Greenville, SC

In the map below, you can see where to find all bus stations in Indianapolis and Greenville, SC.

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

McDonald's

Woodruff Rd 1111

N Church St

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

Woodruff Rd

Woodruff Rd 1116

Service and Comfort on the bus from Indianapolis to Greenville, SC

Want to know which seat classes are available on the buses from Indianapolis to Greenville, SC? Or which bus companies serve the route Indianapolis to Greenville, SC? Below you will find answers to your questions.

FAQs about the Indianapolis to Greenville, SC bus

How much does a Indianapolis Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $77 and takes 16h 5m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Indianapolis to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $77 and $102. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Indianapolis to Greenville, SC each day?

Every day, the Indianapolis to Greenville, SC bus route is served by approximately 10 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Indianapolis to Greenville, SC take?

The fastest bus from Indianapolis to Greenville, SC is offered by Greyhound US and takes 14h 55m. Bus tickets for this connection cost $96. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Indianapolis to Greenville, SC?

The earliest bus arriving in Greenville, SC from Indianapolis starts at 4:05 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Indianapolis to Greenville, SC?

The latest bus trip departing from Indianapolis for Greenville, SC starts at 11:25 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Indianapolis Greenville, SC route?

When traveling by bus from Indianapolis to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Indianapolis and Greenville, SC?

You can check all the direct connections between Indianapolis and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Indianapolis to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Indianapolis Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Indianapolis Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Indianapolis to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Indianapolis to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 10 daily trips between Indianapolis and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Indianapolis to Greenville, SC?

Prices and availability for 10 trips between Indianapolis and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Indianapolis to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Indianapolis and to Greenville, SC

Here’s an overview of the most popular bus routes to Indianapolis and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!