Bus Columbia, MO to Chicago: Compare prices and save money

Compare all timetables for the bus from Columbia, MO to Chicago

Here is a selection of the cheapest bus trips from the schedule from Columbia, MO to Chicago from various bus operators like Greyhound US for the next days.

today

tomorrow

$60

Monday

$57

Tuesday

$54

Wednesday

$56

Thursday

$54

Friday

$57

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	13h 35m	8:30 AM	Columbia, MO	Bus Stop	10:05 PM	Chicago	Downtown Bus Station	Economy	$60	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/26/2026 8:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/26/2026 10:05:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 13h 35m
Greyhound US	11h 25m	10:40 AM	Columbia, MO	Red Thread	10:05 PM	Chicago	Downtown Bus Station	Economy	$60	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/26/2026 10:40:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/26/2026 10:05:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 11h 25m
Greyhound US	9h 10m	8:35 PM	Columbia, MO	Red Thread	5:45 AM	Chicago	Downtown Bus Station	Economy	$60	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/26/2026 8:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/27/2026 5:45:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 9h 10m
Greyhound US	9h 40m	8:05 PM	Columbia, MO	Bus Stop	5:45 AM	Chicago	Downtown Bus Station	Economy	$61	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/26/2026 8:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/27/2026 5:45:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 9h 40m
Greyhound US	17h 10m	8:35 PM	Columbia, MO	Red Thread	1:45 PM	Chicago	Canal & Van Buren	Economy	$67	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/26/2026 8:35:00 PM to Canal & Van Buren, Chicago (USA) arriving at 7/27/2026 1:45:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 17h 10m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	9h 40m	8:05 PM	Columbia, MO	Bus Stop	5:45 AM	Chicago	Downtown Bus Station	Economy	$57	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/27/2026 8:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/28/2026 5:45:00 AM. 50 Economy ticket for $57 per person are available. Travel duration is 9h 40m
Greyhound US	13h 35m	8:30 AM	Columbia, MO	Bus Stop	10:05 PM	Chicago	Downtown Bus Station	Economy	$58	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/27/2026 8:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/27/2026 10:05:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 13h 35m
Greyhound US	11h 25m	10:40 AM	Columbia, MO	Red Thread	10:05 PM	Chicago	Downtown Bus Station	Economy	$59	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/27/2026 10:40:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/27/2026 10:05:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 11h 25m
Greyhound US	9h 10m	8:35 PM	Columbia, MO	Red Thread	5:45 AM	Chicago	Downtown Bus Station	Economy	$59	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/27/2026 8:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/28/2026 5:45:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 9h 10m
Greyhound US	15h 5m	8:30 AM	Columbia, MO	Bus Stop	11:35 PM	Chicago	95th Red Line Station	Economy	$65	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/27/2026 8:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/27/2026 11:35:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 15h 5m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	13h 35m	8:30 AM	Columbia, MO	Bus Stop	10:05 PM	Chicago	Downtown Bus Station	Economy	$54	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/28/2026 8:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/28/2026 10:05:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 13h 35m
Greyhound US	9h 40m	8:05 PM	Columbia, MO	Bus Stop	5:45 AM	Chicago	Downtown Bus Station	Economy	$54	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/28/2026 8:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/29/2026 5:45:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 9h 40m
Greyhound US	9h 10m	8:35 PM	Columbia, MO	Red Thread	5:45 AM	Chicago	Downtown Bus Station	Economy	$55	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/28/2026 8:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/29/2026 5:45:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 9h 10m
Greyhound US	11h 25m	10:40 AM	Columbia, MO	Red Thread	10:05 PM	Chicago	Downtown Bus Station	Economy	$58	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/28/2026 10:40:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/28/2026 10:05:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 11h 25m
Greyhound US	15h 5m	8:30 AM	Columbia, MO	Bus Stop	11:35 PM	Chicago	95th Red Line Station	Economy	$61	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/28/2026 8:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/28/2026 11:35:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 5m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	9h 40m	8:05 PM	Columbia, MO	Bus Stop	5:45 AM	Chicago	Downtown Bus Station	Economy	$56	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/29/2026 8:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/30/2026 5:45:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 9h 40m
Greyhound US	9h 10m	8:35 PM	Columbia, MO	Red Thread	5:45 AM	Chicago	Downtown Bus Station	Economy	$56	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/29/2026 8:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/30/2026 5:45:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 9h 10m
Greyhound US	13h 35m	8:30 AM	Columbia, MO	Bus Stop	10:05 PM	Chicago	Downtown Bus Station	Economy	$57	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/29/2026 8:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/29/2026 10:05:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 13h 35m
Greyhound US	8h 45m	8:35 PM	Columbia, MO	Red Thread	5:20 AM	Chicago	95th Red Line Station	Economy	$59	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/29/2026 8:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2026 5:20:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 8h 45m
Greyhound US	15h 5m	8:30 AM	Columbia, MO	Bus Stop	11:35 PM	Chicago	95th Red Line Station	Economy	$60	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/29/2026 8:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/29/2026 11:35:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 15h 5m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	13h 35m	8:30 AM	Columbia, MO	Bus Stop	10:05 PM	Chicago	Downtown Bus Station	Economy	$54	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/30/2026 8:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/30/2026 10:05:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 13h 35m
Greyhound US	9h 40m	8:05 PM	Columbia, MO	Bus Stop	5:45 AM	Chicago	Downtown Bus Station	Economy	$54	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/30/2026 8:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/31/2026 5:45:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 9h 40m
Greyhound US	11h 25m	10:40 AM	Columbia, MO	Red Thread	10:05 PM	Chicago	Downtown Bus Station	Economy	$54	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/30/2026 10:40:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/30/2026 10:05:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 11h 25m
Greyhound US	9h 10m	8:35 PM	Columbia, MO	Red Thread	5:45 AM	Chicago	Downtown Bus Station	Economy	$54	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/30/2026 8:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/31/2026 5:45:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 9h 10m
Greyhound US	15h 5m	8:30 AM	Columbia, MO	Bus Stop	11:35 PM	Chicago	95th Red Line Station	Economy	$56	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/30/2026 8:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2026 11:35:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 15h 5m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	13h 35m	8:30 AM	Columbia, MO	Bus Stop	10:05 PM	Chicago	Downtown Bus Station	Economy	$57	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/31/2026 8:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/31/2026 10:05:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 13h 35m
Greyhound US	9h 40m	8:05 PM	Columbia, MO	Bus Stop	5:45 AM	Chicago	Downtown Bus Station	Economy	$58	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/31/2026 8:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 8/1/2026 5:45:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 9h 40m
Greyhound US	11h 25m	10:40 AM	Columbia, MO	Red Thread	10:05 PM	Chicago	Downtown Bus Station	Economy	$58	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/31/2026 10:40:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/31/2026 10:05:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 11h 25m
Greyhound US	9h 10m	8:35 PM	Columbia, MO	Red Thread	5:45 AM	Chicago	Downtown Bus Station	Economy	$58	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/31/2026 8:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 8/1/2026 5:45:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 9h 10m
Greyhound US	9h 15m	8:05 PM	Columbia, MO	Bus Stop	5:20 AM	Chicago	95th Red Line Station	Economy	$68	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/31/2026 8:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 8/1/2026 5:20:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 9h 15m

Best Price Offer: The price for the cheapest bus from Columbia, MO to Chicago is $48 on 8/8/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Columbia, MO and Chicago

See here how frequent the connections between Columbia, MO and Chicago are, during different times and days of the week.

Thursday is the busiest day, with more than 23 daily buses from Columbia, MO to Chicago. Monday has instead the fewest connections, with only 10 daily coaches between Columbia, MO and Chicago.

The busiest time of the day is the Evening, with 62 buses from Columbia, MO to Chicago, while Morning sees the fewest connections between Columbia, MO and Chicago, with 41 offers.

Facts about the bus from Columbia, MO to Chicago

Compare all providers like Greyhound US that travel 17 times every day by bus from Columbia, MO to Chicago in one click! Book your bus ticket from Columbia, MO to Chicago starting from $48!

Cheapest Bus	$48
Fastest Bus	8h 45m
Earliest Bus	8:30 AM
Latest Bus	8:35 PM
Daily Bus Routes	17 Ø
Distance	318.7 miles
Bus Companies	Greyhound US

Cheapest bus connections from Columbia, MO to Chicago

Every day, 17 buses from 1 bus companies leave Columbia, MO for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

Sunday 07/26

$60

Monday 07/27

$57

Tuesday 07/28

$54

Wednesday 07/29

$59

Thursday 07/30

$54

Friday 07/31

$57

Saturday 08/01

$59

Sunday 08/02

$56

Monday 08/03

Tuesday 08/04

$59

Wednesday 08/05

$55

Thursday 08/06

$57

Friday 08/07

$58

Saturday 08/08

$48

Sunday 08/09

$58

Monday 08/10

$67

Tuesday 08/11

$63

Wednesday 08/12

$51

Thursday 08/13

$63

Friday 08/14

Saturday 08/15

The cheapest time to travel from Columbia, MO to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from Columbia, MO to Chicago, for the next 30 days.

With a price starting from $51, Wednesday is the cheapest day for a bus from Columbia, MO to Chicago. Monday instead is the most expensive day with prices starting from $57.

Evening is the cheapest day time for bus tickets from Columbia, MO to Chicago, with $54. Morning is the most expensive time of the day with prices starting from $54.

How to save money travelling from Columbia, MO to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Columbia, MO to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Columbia, MO to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Columbia, MO to Chicago are also emptier.

All bus stations and stops in Columbia, MO and Chicago

In the map below, you can see where to find all bus stations in Columbia, MO and Chicago.

University

Fellows Pl 1301-1349

Bus Stop

N 10th St 198

Red Thread

Highway 40 W 6401

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Canal & Van Buren

S Canal St 310-320

W Cermak Rd

W Cermak Rd 1001

Service and Comfort on the bus from Columbia, MO to Chicago

Want to know which seat classes are available on the buses from Columbia, MO to Chicago? Or which bus companies serve the route Columbia, MO to Chicago? Below you will find answers to your questions.

FAQs about the Columbia, MO to Chicago bus

How much does a Columbia, MO Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $48 and takes 9h 40m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Columbia, MO to Chicago?

This route is offered by 1 companies with a range of ticket prices between $48 and $88. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Columbia, MO to Chicago each day?

Every day, the Columbia, MO to Chicago bus route is served by approximately 17 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Columbia, MO to Chicago take?

The fastest bus from Columbia, MO to Chicago is offered by Greyhound US and takes 8h 45m. Bus tickets for this connection cost $71. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Columbia, MO to Chicago?

The earliest bus arriving in Chicago from Columbia, MO starts at 8:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Columbia, MO to Chicago?

The latest bus trip departing from Columbia, MO for Chicago starts at 8:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Columbia, MO Chicago route?

When traveling by bus from Columbia, MO to Chicago, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Columbia, MO and Chicago?

You can check all the direct connections between Columbia, MO and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Columbia, MO to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Columbia, MO Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Columbia, MO Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Columbia, MO to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Columbia, MO to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 17 daily trips between Columbia, MO and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Columbia, MO to Chicago?

Prices and availability for 17 trips between Columbia, MO and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Columbia, MO to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Columbia, MO and to Chicago

Here’s an overview of the most popular bus routes to Columbia, MO and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!